2-(2-fluorophenylmethyl)-6-(4-hydroxyphenyl)-8-benzyl-3,7-dihydroimidazo[1,2-a]pyrazine-3-one

Base Information

Chemical Name:2-(2-fluorophenylmethyl)-6-(4-hydroxyphenyl)-8-benzyl-3,7-dihydroimidazo[1,2-a]pyrazine-3-one
CAS No.:423184-51-4
Molecular Formula:C₂₆H₂₀FN₃O₂
Molecular Weight:425.462
Hs Code.:

Synonyms:2-(2-fluorophenylmethyl)-6-(4-hydroxyphenyl)-8-benzyl-3,7-dihydroimidazo[1,2-a]pyrazine-3-one

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Chemical Property of 2-(2-fluorophenylmethyl)-6-(4-hydroxyphenyl)-8-benzyl-3,7-dihydroimidazo[1,2-a]pyrazine-3-one

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Technology Process of 2-(2-fluorophenylmethyl)-6-(4-hydroxyphenyl)-8-benzyl-3,7-dihydroimidazo[1,2-a]pyrazine-3-one

There total 7 articles about 2-(2-fluorophenylmethyl)-6-(4-hydroxyphenyl)-8-benzyl-3,7-dihydroimidazo[1,2-a]pyrazine-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 37156-84-6
4-(5-amino-6-benzyl-pyrazin-2-yl)-phenol

: 3-(2-fluorophenyl)-2-hydroxy-2-propen-1-al

: 423184-51-4
2-(2-fluorophenylmethyl)-6-(4-hydroxyphenyl)-8-benzyl-3,7-dihydroimidazo[1,2-a]pyrazine-3-one

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; water; at 80 ℃; for 2h;
DOI:10.1016/S0040-4020(02)00100-X

Reference yield:

: 451-82-1
(2-fluorophenyl)acetic acid

: 423184-51-4
2-(2-fluorophenylmethyl)-6-(4-hydroxyphenyl)-8-benzyl-3,7-dihydroimidazo[1,2-a]pyrazine-3-one

Guidance literature:: Multi-step reaction with 7 steps

1: SOCl₂ / 2 h / Heating

2: diethyl ether / -78 - 0 °C

3: 1.0 g / 47 percent HBr / acetic acid / 0 - 20 °C

4: CH₂Cl₂ / 3 h / 70 °C

5: aq. NaOH / 0 - 20 °C

6: 503 mg / aq. H₂SO₄ / 1.5 h / 20 °C

7: 65 percent / aq. HCl / H₂O; dioxane / 2 h / 80 °C

With hydrogenchloride; sodium hydroxide; thionyl chloride; sulfuric acid; hydrogen bromide; In 1,4-dioxane; diethyl ether; dichloromethane; water; acetic acid;
DOI:10.1016/S0040-4020(02)00100-X

Reference yield:

: 423184-32-1
1-bromo-3-(2-fluorophenyl)-propan-2-one

: 423184-51-4
2-(2-fluorophenylmethyl)-6-(4-hydroxyphenyl)-8-benzyl-3,7-dihydroimidazo[1,2-a]pyrazine-3-one

Guidance literature:: Multi-step reaction with 4 steps

1: CH₂Cl₂ / 3 h / 70 °C

2: aq. NaOH / 0 - 20 °C

3: 503 mg / aq. H₂SO₄ / 1.5 h / 20 °C

4: 65 percent / aq. HCl / H₂O; dioxane / 2 h / 80 °C

With hydrogenchloride; sodium hydroxide; sulfuric acid; In 1,4-dioxane; dichloromethane; water;
DOI:10.1016/S0040-4020(02)00100-X