N₅,1-dimethyl-N₅-[2-((4-[(methylsulfonyl)methyl]phenyl)amino)pyrimidin-4-yl]-1H-benzimidazole-2,5-diamine

Base Information

• Chemical Name: N₅,1-dimethyl-N₅-[2-((4-[(methylsulfonyl)methyl]phenyl)amino)pyrimidin-4-yl]-1H-benzimidazole-2,5-diamine
• CAS No.: 596131-73-6
• Molecular Formula: C₂₁H₂₃N₇O₂S
• Molecular Weight: 437.525

Synonyms:N₅,1-dimethyl-N₅-[2-((4-[(methylsulfonyl)methyl]phenyl)amino)pyrimidin-4-yl]-1H-benzimidazole-2,5-diamine

Chemical Property of N₅,1-dimethyl-N₅-[2-((4-[(methylsulfonyl)methyl]phenyl)amino)pyrimidin-4-yl]-1H-benzimidazole-2,5-diamine

Chemical Property:

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Technology Process of N₅,1-dimethyl-N₅-[2-((4-[(methylsulfonyl)methyl]phenyl)amino)pyrimidin-4-yl]-1H-benzimidazole-2,5-diamine

There total 2 articles about N₅,1-dimethyl-N₅-[2-((4-[(methylsulfonyl)methyl]phenyl)amino)pyrimidin-4-yl]-1H-benzimidazole-2,5-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 5-[(2-chloropyrimidin-4-yl)(methyl)amino]-1-methyl-1H-benzimidazol-2-ylcarbamate (596131-72-5) + 4-[(methylsulfonyl)methyl]aniline (24176-70-3) → N5,1-dimethyl-N5-[2-((4-[(methylsulfonyl)methyl]phenyl)amino)pyrimidin-4-yl]-1H-benzimidazole-2,5-diamine (596131-73-6)

Guidance literature:

tert-butyl 5-[(2-chloropyrimidin-4-yl)(methyl)amino]-1-methyl-1H-benzimidazol-2-ylcarbamate; 4-[(methylsulfonyl)methyl]aniline; With hydrogenchloride; In 1,4-dioxane; isopropyl alcohol; at 85 ℃; for 48h;

With sodium hydrogencarbonate; In 1,4-dioxane; water; isopropyl alcohol; Product distribution / selectivity;

Reference yield:

N5-(2-chloropyrimidin-4-yl)-N5,1-dimethyl-1H-benzimidazole-2,5-diamine + 4-[(methylsulfonyl)methyl]aniline (24176-70-3) → N5,1-dimethyl-N5-[2-((4-[(methylsulfonyl)methyl]phenyl)amino)pyrimidin-4-yl]-1H-benzimidazole-2,5-diamine (596131-73-6)

Guidance literature:

With hydrogenchloride; In diethyl ether; ethanol; at 70 ℃; for 5h; Product distribution / selectivity;

Reference yield:

Thiophene-2-acetic acid (1918-77-0) + N5,1-dimethyl-N5-[2-((4-[(methylsulfonyl)methyl]phenyl)amino)pyrimidin-4-yl]-1H-benzimidazole-2,5-diamine (596131-73-6) → C27H27N7O3S2

Guidance literature:

Thiophene-2-acetic acid; With 1,1'-carbonyldiimidazole; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 0.25h;

N₅,1-dimethyl-N₅-[2-((4-[(methylsulfonyl)methyl]phenyl)amino)pyrimidin-4-yl]-1H-benzimidazole-2,5-diamine; With triethylamine; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 16h;

upstream raw materials:

tert-butyl 5-[(2-chloropyrimidin-4-yl)(methyl)amino]-1-methyl-1H-benzimidazol-2-ylcarbamate

4-[(methylsulfonyl)methyl]aniline

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