1-(5-tert-butyl-2-methoxy-3-((S)-2,2,2-trifluoro-1-hydroxyethyl)phenyl)-3-((1S,2R)-1-hydroxy-2,3-dihydro-1H-indene-2-yl)urea

Base Information

Chemical Name:1-(5-tert-butyl-2-methoxy-3-((S)-2,2,2-trifluoro-1-hydroxyethyl)phenyl)-3-((1S,2R)-1-hydroxy-2,3-dihydro-1H-indene-2-yl)urea
CAS No.:1283525-70-1
Molecular Formula:C₂₃H₂₇F₃N₂O₄
Molecular Weight:452.474
Hs Code.:

Synonyms:1-(5-tert-butyl-2-methoxy-3-((S)-2,2,2-trifluoro-1-hydroxyethyl)phenyl)-3-((1S,2R)-1-hydroxy-2,3-dihydro-1H-indene-2-yl)urea

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Chemical Property of 1-(5-tert-butyl-2-methoxy-3-((S)-2,2,2-trifluoro-1-hydroxyethyl)phenyl)-3-((1S,2R)-1-hydroxy-2,3-dihydro-1H-indene-2-yl)urea

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Technology Process of 1-(5-tert-butyl-2-methoxy-3-((S)-2,2,2-trifluoro-1-hydroxyethyl)phenyl)-3-((1S,2R)-1-hydroxy-2,3-dihydro-1H-indene-2-yl)urea

There total 5 articles about 1-(5-tert-butyl-2-methoxy-3-((S)-2,2,2-trifluoro-1-hydroxyethyl)phenyl)-3-((1S,2R)-1-hydroxy-2,3-dihydro-1H-indene-2-yl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 1283526-62-4
2,2,2-trichloroethyl 5-tert-butyl-2-methoxy-3-(2,2,2-trifluoro-1-hydroxyethyl)phenylcarbamate

: (1S,2R)-2-amino-2,3-dihydro-1H-indene-1-ol.L-tartaric acid salt

: 1283525-70-1
1-(5-tert-butyl-2-methoxy-3-((S)-2,2,2-trifluoro-1-hydroxyethyl)phenyl)-3-((1S,2R)-1-hydroxy-2,3-dihydro-1H-indene-2-yl)urea

: 1283525-71-2
C₂₃H₂₇F₃N₂O₄

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; Reflux;

Reference yield:

: 1283526-57-7
1-(5-tert-butyl-2-methoxy-3-nitrophenyl)-2,2,2-trifluoroethanol

: 1283525-70-1
1-(5-tert-butyl-2-methoxy-3-((S)-2,2,2-trifluoro-1-hydroxyethyl)phenyl)-3-((1S,2R)-1-hydroxy-2,3-dihydro-1H-indene-2-yl)urea

: 1283525-71-2
C₂₃H₂₇F₃N₂O₄

Guidance literature:: Multi-step reaction with 3 steps

1: ammonium chloride; iron / ethanol; water / 15 h / Reflux

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.17 h / 0 °C

3: N-ethyl-N,N-diisopropylamine / acetonitrile / Reflux

With iron; ammonium chloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; water; acetonitrile;

Reference yield:

: 1283526-60-2
1-(3-amino-5-tert-butyl-2-methoxyphenyl)-2,2,2-trifluoroethanol

: 1283525-70-1
1-(5-tert-butyl-2-methoxy-3-((S)-2,2,2-trifluoro-1-hydroxyethyl)phenyl)-3-((1S,2R)-1-hydroxy-2,3-dihydro-1H-indene-2-yl)urea

: 1283525-71-2
C₂₃H₂₇F₃N₂O₄

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.17 h / 0 °C

2: N-ethyl-N,N-diisopropylamine / acetonitrile / Reflux

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; acetonitrile;