N-ethyl-4-((4-(isoindolin-2-yl)-1,3,5-triazin-2-ylamino)methyl)-N-m-tolylbenzamide

Base Information

Chemical Name:N-ethyl-4-((4-(isoindolin-2-yl)-1,3,5-triazin-2-ylamino)methyl)-N-m-tolylbenzamide
CAS No.:1236265-36-3
Molecular Formula:C₂₈H₂₈N₆O
Molecular Weight:464.57
Hs Code.:

Synonyms:N-ethyl-4-((4-(isoindolin-2-yl)-1,3,5-triazin-2-ylamino)methyl)-N-m-tolylbenzamide

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Chemical Property of N-ethyl-4-((4-(isoindolin-2-yl)-1,3,5-triazin-2-ylamino)methyl)-N-m-tolylbenzamide

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Technology Process of N-ethyl-4-((4-(isoindolin-2-yl)-1,3,5-triazin-2-ylamino)methyl)-N-m-tolylbenzamide

There total 5 articles about N-ethyl-4-((4-(isoindolin-2-yl)-1,3,5-triazin-2-ylamino)methyl)-N-m-tolylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 496-12-8
isoindoline

: 1236266-06-0
4-((4-chloro-1,3,5-triazin-2-ylamino)methyl)-N-ethyl-N-m-tolylbenzamide

: 1236265-36-3
N-ethyl-4-((4-(isoindolin-2-yl)-1,3,5-triazin-2-ylamino)methyl)-N-m-tolylbenzamide

Guidance literature:: In 1-methyl-pyrrolidin-2-one; at 80 ℃; for 1h;

Reference yield:

: 33233-67-9
4-(tert-Butoxycarbonylaminomethyl)benzoic acid

: 1236265-36-3
N-ethyl-4-((4-(isoindolin-2-yl)-1,3,5-triazin-2-ylamino)methyl)-N-m-tolylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C / Cooling with ice

2: dichloromethane / 0.33 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 0 - 20 °C

4: 1-methyl-pyrrolidin-2-one / 1 h / 80 °C

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; dichloromethane;
DOI:10.1021/acsmedchemlett.5b00138

Reference yield:

: 102-27-2
N-ethyl-m-toulidine

: 1236265-36-3
N-ethyl-4-((4-(isoindolin-2-yl)-1,3,5-triazin-2-ylamino)methyl)-N-m-tolylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C / Cooling with ice

2: dichloromethane / 0.33 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 0 - 20 °C

4: 1-methyl-pyrrolidin-2-one / 1 h / 80 °C

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; dichloromethane;
DOI:10.1021/acsmedchemlett.5b00138