(R)-6-((R)-6-(tert-butyldiphenylsilyloxy)heptyl)-5,6-dihydro-2H-pyran-2-one

Base Information

Chemical Name:(R)-6-((R)-6-(tert-butyldiphenylsilyloxy)heptyl)-5,6-dihydro-2H-pyran-2-one
CAS No.:1610046-45-1
Molecular Formula:C₂₈H₃₈O₃Si
Molecular Weight:450.693
Hs Code.:

Synonyms:(R)-6-((R)-6-(tert-butyldiphenylsilyloxy)heptyl)-5,6-dihydro-2H-pyran-2-one

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Chemical Property of (R)-6-((R)-6-(tert-butyldiphenylsilyloxy)heptyl)-5,6-dihydro-2H-pyran-2-one

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Technology Process of (R)-6-((R)-6-(tert-butyldiphenylsilyloxy)heptyl)-5,6-dihydro-2H-pyran-2-one

There total 12 articles about (R)-6-((R)-6-(tert-butyldiphenylsilyloxy)heptyl)-5,6-dihydro-2H-pyran-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1610046-44-0
(4R,10R)-10-(tert-butyldiphenylsilyloxy)undec-1-en-4-ylacrylate

: 1610046-45-1
(R)-6-((R)-6-(tert-butyldiphenylsilyloxy)heptyl)-5,6-dihydro-2H-pyran-2-one

Guidance literature:: With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane;
DOI:10.1016/j.tetlet.2014.04.026

Reference yield:

: C₂₂H₃₁NO₄

: 1610046-45-1
(R)-6-((R)-6-(tert-butyldiphenylsilyloxy)heptyl)-5,6-dihydro-2H-pyran-2-one

Guidance literature:: Multi-step reaction with 9 steps

1.1: acetic acid; zinc / ethanol / 12 h / 20 °C

2.1: di(n-butyl)tin oxide; triethylamine / dichloromethane / 0 - 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / Reflux; Inert atmosphere

4.1: 1H-imidazole / dichloromethane / 0.17 h / 0 °C

4.2: 6 h / 0 - 20 °C

5.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane; water / 2 h / 0 - 20 °C

6.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide; dichloromethane / 3 h / 20 °C

7.1: (S)-[1,1']-binaphthalenyl-2,2'-diol; titanium(IV)isopropoxide / dichloromethane / 0.5 h / 20 °C / Inert atmosphere; Molecular sieve

7.2: 24 h / -78 - -20 °C / Inert atmosphere; Molecular sieve

8.1: dmap / 1 h / 0 - 20 °C / Inert atmosphere

9.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane

With 1H-imidazole; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; dmap; lithium aluminium tetrahydride; (S)-[1,1']-binaphthalenyl-2,2'-diol; titanium(IV)isopropoxide; di(n-butyl)tin oxide; acetic acid; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; zinc; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide;
DOI:10.1016/j.tetlet.2014.04.026

Reference yield:

: 667419-30-9
(2R)-8-(4-methoxyphenylmethoxy)octan-2-ol

: 1610046-45-1
(R)-6-((R)-6-(tert-butyldiphenylsilyloxy)heptyl)-5,6-dihydro-2H-pyran-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1H-imidazole / dichloromethane / 0.17 h / 0 °C

1.2: 6 h / 0 - 20 °C

2.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane; water / 2 h / 0 - 20 °C

3.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide; dichloromethane / 3 h / 20 °C

4.1: (S)-[1,1']-binaphthalenyl-2,2'-diol; titanium(IV)isopropoxide / dichloromethane / 0.5 h / 20 °C / Inert atmosphere; Molecular sieve

4.2: 24 h / -78 - -20 °C / Inert atmosphere; Molecular sieve

5.1: dmap / 1 h / 0 - 20 °C / Inert atmosphere

6.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane

With 1H-imidazole; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; dmap; (S)-[1,1']-binaphthalenyl-2,2'-diol; titanium(IV)isopropoxide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In dichloromethane; water; dimethyl sulfoxide;
DOI:10.1016/j.tetlet.2014.04.026