Chemical Property of Methenamine hippurate
Chemical Property:
- Appearance/Colour:white crystalline
powder
- Vapor Pressure:2.06E-09mmHg at 25°C
- Melting Point:89-95oC
- Boiling Point:464.1°Cat760mmHg
- Flash Point:234.5°C
- PSA：79.36000
- Density:g/cm3
- LogP:-0.37630
- Storage Temp.:Refrigerator
- Solubility.:DMSO (Slightly), Methanol (Slightly)
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:7
- Rotatable Bond Count:3
- Exact Mass:319.16443955
- Heavy Atom Count:23
- Complexity:282
- Purity/Quality:
-
99%, *data from raw suppliers
MethenamineHippurate *data from reagent suppliers
Safty Information:
- Pictogram(s):
UN NO.
- Hazard Codes:UN NO.
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:C1N2CN3CN1CN(C2)C3.C1=CC=C(C=C1)C(=O)NCC(=O)O
- Recent ClinicalTrials:Urinary Track Infection Prevention After Urogynecological Surgery
- Recent EU Clinical Trials:The effect of methenamine hippurate to reduce antibiotic prescribing due to new episodes of urinary tract infections (UTI) in elderly women with recurrent UTI – a triple-blinded,randomized placebo-controlled phase IV study
-
Description
Methenamine hippurate is a broad-spectrum urinary antiseptic agent. Under acidic conditions, methenamine hippurate is hydrolyzed to formaldehyde and ammonia, which exerts an antibacterial effect. It is effective against a wide range of bacteria but lacks activity against Proteus and other bacteria that increase urine alkalinity. Formulations containing methenamine hippurate have been used to treat urinary tract infections.
-
Therapeutic Function
Antibacterial (urinary)
-
Clinical Use
Antibacterial agent
-
Drug interactions
Potentially hazardous interactions with other drugs
Antibacterials: increased risk of crystalluria with
sulphonamides.
Diuretics: effects antagonised by acetazolamide.
