(6-chloro-4-cyclopropyl-3,4-dihydro-2H-quinoxalin-1-yl)-[4-(2,5-dichloro-phenoxy)-pyridin-3-yl]-methanone

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Chemical Name:(6-chloro-4-cyclopropyl-3,4-dihydro-2H-quinoxalin-1-yl)-[4-(2,5-dichloro-phenoxy)-pyridin-3-yl]-methanone
CAS No.:1315468-60-0
Molecular Formula:C₂₃H₁₈Cl₃N₃O₂
Molecular Weight:474.774
Hs Code.:

Synonyms:(6-chloro-4-cyclopropyl-3,4-dihydro-2H-quinoxalin-1-yl)-[4-(2,5-dichloro-phenoxy)-pyridin-3-yl]-methanone

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Chemical Property of (6-chloro-4-cyclopropyl-3,4-dihydro-2H-quinoxalin-1-yl)-[4-(2,5-dichloro-phenoxy)-pyridin-3-yl]-methanone

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Technology Process of (6-chloro-4-cyclopropyl-3,4-dihydro-2H-quinoxalin-1-yl)-[4-(2,5-dichloro-phenoxy)-pyridin-3-yl]-methanone

There total 11 articles about (6-chloro-4-cyclopropyl-3,4-dihydro-2H-quinoxalin-1-yl)-[4-(2,5-dichloro-phenoxy)-pyridin-3-yl]-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 1315469-36-3
(4-cyclopropyl-3,4-dihydro-2H-quinoxalin-1-yl)-[4-(2,5-dichloro-phenoxy)-1-oxy-pyridin-3-yl]-methanone

: 1315468-60-0
(6-chloro-4-cyclopropyl-3,4-dihydro-2H-quinoxalin-1-yl)-[4-(2,5-dichloro-phenoxy)-pyridin-3-yl]-methanone

Guidance literature:: (4-cyclopropyl-3,4-dihydro-2H-quinoxalin-1-yl)-[4-(2,5-dichloro-phenoxy)-1-oxy-pyridin-3-yl]-methanone; With methyl chloroformate; 1,1,1,3,3,3-hexamethyl-disilazane; In tetrahydrofuran; at 20 ℃; for 1.5h;

With sodium hydrogencarbonate; In tetrahydrofuran; water;

Reference yield:

: 1493-27-2,127723-77-7
ortho-nitrofluorobenzene

: 1315468-60-0
(6-chloro-4-cyclopropyl-3,4-dihydro-2H-quinoxalin-1-yl)-[4-(2,5-dichloro-phenoxy)-pyridin-3-yl]-methanone

Guidance literature:: Multi-step reaction with 7 steps

1: 19 h / 20 - 30 °C

2: triethylamine / dichloromethane / 72 h / 20 °C

3: hydrogen / palladium 10% on activated carbon / methanol / 2 h / 20 °C / 900.09 Torr

4: triphenylphosphine / N,N-dimethyl-formamide / 4 h / 135 °C

5: borane-THF / tetrahydrofuran / 20 °C

6: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C

7: 1,1,1,3,3,3-hexamethyl-disilazane; methyl chloroformate / tetrahydrofuran / 1.5 h / 20 °C

With borane-THF; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; methyl chloroformate; triphenylphosphine; 1,1,1,3,3,3-hexamethyl-disilazane; HATU; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1224640-10-1
N-cyclopropyl-N-(2-nitro-phenyl)-oxalamic acid methyl ester

: 1315468-60-0
(6-chloro-4-cyclopropyl-3,4-dihydro-2H-quinoxalin-1-yl)-[4-(2,5-dichloro-phenoxy)-pyridin-3-yl]-methanone

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 2 h / 20 °C / 900.09 Torr

2: triphenylphosphine / N,N-dimethyl-formamide / 4 h / 135 °C

3: borane-THF / tetrahydrofuran / 20 °C

4: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C

5: 1,1,1,3,3,3-hexamethyl-disilazane; methyl chloroformate / tetrahydrofuran / 1.5 h / 20 °C

With borane-THF; hydrogen; N-ethyl-N,N-diisopropylamine; methyl chloroformate; triphenylphosphine; 1,1,1,3,3,3-hexamethyl-disilazane; HATU; palladium 10% on activated carbon; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;