2-bromo-6-methoxybenzoyl chloride

Base Information

• Chemical Name: 2-bromo-6-methoxybenzoyl chloride
• CAS No.: 1261645-01-5
• Molecular Formula: C₈H₆BrClO₂
• Molecular Weight: 249.491
• Mol file: 1261645-01-5.mol

Synonyms:2-bromo-6-methoxybenzoyl chloride

Chemical Property of 2-bromo-6-methoxybenzoyl chloride

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

2-Bromo-6-methoxybenzoylChloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 2-Bromo-6-methoxybenzoyl Chloride is an intermediate used in the synthesis of Fluoren-1-ol (F462450), which is a metabolite of the PAH micropollutant Fluorene (F462002) with potential mutagenic effects. It is used as biomarkers to evaluate exposure to PAHs and environmental tobacco smoke in general population.

Technology Process of 2-bromo-6-methoxybenzoyl chloride

There total 1 articles about 2-bromo-6-methoxybenzoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromo-6-methoxybenzoic acid (31786-45-5) → 2-bromo-6-methoxybenzoyl chloride (1261645-01-5)

Guidance literature:

With thionyl chloride;

DOI:10.1002/jlcr.3066

Reference yield: 93.0%

naphtho[2,3-d][1,3]dioxol-5-amine (53811-49-7) + 2-bromo-6-methoxybenzoyl chloride (1261645-01-5) → 2-bromo-6-methoxy-N-(naphtho[2,3-d][1,3]dioxol-5-yl)benzamide

Guidance literature:

With trimethylamine; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1021/acs.jmedchem.1c00318

Reference yield: 85.0%

2-bromo-6-methoxybenzoyl chloride (1261645-01-5) + 1-amino-naphthalene (134-32-7) → 2-bromo-6-methoxy-N-(naphthalen-1-yl)benzamide

Guidance literature:

With trimethylamine; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1021/acs.jmedchem.1c00318

upstream raw materials:

2-bromo-6-methoxybenzoic acid