4-[2-[4-(4-chlorphenyl)thiazol-2-yl]-2-(4-trifluoromethoxyphenyl)ethyl]benzoic acid

Base Information

Chemical Name:4-[2-[4-(4-chlorphenyl)thiazol-2-yl]-2-(4-trifluoromethoxyphenyl)ethyl]benzoic acid
CAS No.:643013-24-5
Molecular Formula:C₂₅H₁₇ClF₃NO₃S
Molecular Weight:503.929
Hs Code.:

Synonyms:4-[2-[4-(4-chlorphenyl)thiazol-2-yl]-2-(4-trifluoromethoxyphenyl)ethyl]benzoic acid

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Chemical Property of 4-[2-[4-(4-chlorphenyl)thiazol-2-yl]-2-(4-trifluoromethoxyphenyl)ethyl]benzoic acid

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Technology Process of 4-[2-[4-(4-chlorphenyl)thiazol-2-yl]-2-(4-trifluoromethoxyphenyl)ethyl]benzoic acid

There total 2 articles about 4-[2-[4-(4-chlorphenyl)thiazol-2-yl]-2-(4-trifluoromethoxyphenyl)ethyl]benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 643013-23-4
4-[2-thiocarbamoyl-2-(4-trifluoromethoxyphenyl)ethyl]benzoic acid methyl ester

: 536-38-9
4-chlorobenzoylmethyl bromide

: 643013-24-5
4-[2-[4-(4-chlorphenyl)thiazol-2-yl]-2-(4-trifluoromethoxyphenyl)ethyl]benzoic acid

Guidance literature:: 4-[2-thiocarbamoyl-2-(4-trifluoromethoxyphenyl)ethyl]benzoic acid methyl ester; 4-chlorobenzoylmethyl bromide; In methanol; for 2h; Heating / reflux;

With sodium hydrogencarbonate; In dichloromethane; water;

With hydrogenchloride; methanol; sodium hydroxide; water; more than 3 stages;

Reference yield:

: 1154062-86-8
C₂₆H₁₉ClF₃NO₃S

: 643013-24-5
4-[2-[4-(4-chlorphenyl)thiazol-2-yl]-2-(4-trifluoromethoxyphenyl)ethyl]benzoic acid

Guidance literature:: With water; sodium hydroxide; In tetrahydrofuran; methanol; at 20 - 38 ℃; for 17h;
DOI:10.1021/jm8016249

Reference yield: 69.0%

: 643013-24-5
4-[2-[4-(4-chlorphenyl)thiazol-2-yl]-2-(4-trifluoromethoxyphenyl)ethyl]benzoic acid

: 3196-73-4
methyl 3-aminopropanoate hydrochloride

: 3-{4-[2-[4-(4-chlorphenyl)thiazol-2-yl]-2-(4-trifluoromethoxyphenyl)ethyl]benzoylamino}propionic acid

Guidance literature:: 4-[2-[4-(4-chlorphenyl)thiazol-2-yl]-2-(4-trifluoromethoxyphenyl)ethyl]benzoic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 1.5h;

methyl 3-aminopropanoate hydrochloride; With N-ethyl-N,N-diisopropylamine; In DMF (N,N-dimethyl-formamide); at 20 - 40 ℃; for 18h;

With hydrogenchloride; methanol; sodium hydroxide; water; more than 3 stages;