1-{2'-[(tert-butyl)dimethylsilyloxy]-4'-[(R)-2-methoxy-2-phenylacetoxy]cyclohexyl}uracil

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Chemical Name:1-{2'-[(tert-butyl)dimethylsilyloxy]-4'-[(R)-2-methoxy-2-phenylacetoxy]cyclohexyl}uracil
CAS No.:878549-92-9
Molecular Formula:C₂₅H₃₆N₂O₆Si
Molecular Weight:488.656
Hs Code.:

Synonyms:1-{2'-[(tert-butyl)dimethylsilyloxy]-4'-[(R)-2-methoxy-2-phenylacetoxy]cyclohexyl}uracil

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Chemical Property of 1-{2'-[(tert-butyl)dimethylsilyloxy]-4'-[(R)-2-methoxy-2-phenylacetoxy]cyclohexyl}uracil

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Technology Process of 1-{2'-[(tert-butyl)dimethylsilyloxy]-4'-[(R)-2-methoxy-2-phenylacetoxy]cyclohexyl}uracil

There total 6 articles about 1-{2'-[(tert-butyl)dimethylsilyloxy]-4'-[(R)-2-methoxy-2-phenylacetoxy]cyclohexyl}uracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: (+/-)-1-{(1'RS,2'RS,4'RS)-2'-[(tert-butyl)dimethylsilyloxy]-4'-hydroxycyclohexyl}uracil

: 3966-32-3
(R)-methoxyphenylacetic acid

: 878550-02-8
1-{2'-[(tert-butyl)dimethylsilyloxy]-4'-[(R)-2-methoxy-2-phenylacetoxy]cyclohexyl}uracil

: 878549-92-9
1-{2'-[(tert-butyl)dimethylsilyloxy]-4'-[(R)-2-methoxy-2-phenylacetoxy]cyclohexyl}uracil

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 4h;
DOI:10.1002/hlca.200590258

Reference yield:

: (+/-)-N-({[(1'RS,2'RS,4'RS)-4'-(benzyloxy)-2'-hydroxycyclohexyl]amino}carbonyl)adenine

: 878549-92-9
1-{2'-[(tert-butyl)dimethylsilyloxy]-4'-[(R)-2-methoxy-2-phenylacetoxy]cyclohexyl}uracil

Guidance literature:: Multi-step reaction with 4 steps

1: 73 percent / H₂SO₄ / H₂O / 2 h / Heating

2: 95 percent / 1H-imidazole / dimethylformamide / 4 h / 20 °C

3: 95 percent / BCl₃ / CH₂Cl₂ / 4 h / -78 °C

4: 43 percent / N,N'-dicyclohexylcarbodiimide; 4-(dimethylamino)pyridine / CH₂Cl₂ / 4 h / 20 °C

With 1H-imidazole; dmap; sulfuric acid; boron trichloride; dicyclohexyl-carbodiimide; In dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1002/hlca.200590258

Reference yield:

: (+/-)-1-[(1'RS,2'RS,4'RS)-4'-(benzyloxy)-2'-hydroxycyclohexyl]uracil

: 878549-92-9
1-{2'-[(tert-butyl)dimethylsilyloxy]-4'-[(R)-2-methoxy-2-phenylacetoxy]cyclohexyl}uracil

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / 1H-imidazole / dimethylformamide / 4 h / 20 °C

2: 95 percent / BCl₃ / CH₂Cl₂ / 4 h / -78 °C

3: 43 percent / N,N'-dicyclohexylcarbodiimide; 4-(dimethylamino)pyridine / CH₂Cl₂ / 4 h / 20 °C

With 1H-imidazole; dmap; boron trichloride; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/hlca.200590258