methyl (2S,3R)-3--2-hydroxy-4-phenylbutanoate

Base Information

Chemical Name:methyl (2S,3R)-3--2-hydroxy-4-phenylbutanoate
CAS No.:124782-04-3
Molecular Formula:C₁₉H₂₁NO₅
Molecular Weight:343.379
Hs Code.:

methyl (2S,3R)-3-<N-(benzyloxycarbonyl)-amino>-2-hydroxy-4-phenylbutanoate

Synonyms:methyl (2S,3R)-3--2-hydroxy-4-phenylbutanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (2S,3R)-3--2-hydroxy-4-phenylbutanoate

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Technology Process of methyl (2S,3R)-3--2-hydroxy-4-phenylbutanoate

There total 9 articles about methyl (2S,3R)-3--2-hydroxy-4-phenylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 137028-93-4
(4R,5S)-4-benzyl-3-benzyloxycarbonyl-2,2-dimethyl-oxazolidine-5-carboxylic acid methyl ester

: 124782-04-3
methyl (2S,3R)-3--2-hydroxy-4-phenylbutanoate

Guidance literature:: With camphor-10-sulfonic acid; In methanol;
DOI:10.1016/j.tetlet.2008.03.114

Reference yield: 88.0%

: (2S,3R)-3-Benzyloxycarbonylamino-2-(tert-butyl-dimethyl-silanyloxy)-4-phenyl-butyric acid methyl ester

: 124782-04-3
methyl (2S,3R)-3--2-hydroxy-4-phenylbutanoate

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃; for 0.5h;
DOI:10.1016/S0040-4039(01)00120-4

Reference yield:

: 152897-52-4
(S)-5-<(S)-2-phenyl-1-(N-tosylamino)ethyl>-1,3-dioxolane

: 124782-04-3
methyl (2S,3R)-3--2-hydroxy-4-phenylbutanoate

Guidance literature:: Multi-step reaction with 5 steps

1: sodium, liquid ammonia / tetrahydrofuran / 0.5 h / -78 °C

2: 30 percent HBr / methanol; acetic acid / Heating

3: NaHCO₃ / methanol; H₂O / Ambient temperature

4: O₂, NaHCO₃ / platinum(IV) oxide / H₂O / 48 h / Ambient temperature

5: tetrahydrofuran / 0 °C

With ammonia; hydrogen bromide; oxygen; sodium; sodium hydrogencarbonate; platinum(IV) oxide; In tetrahydrofuran; methanol; water; acetic acid;
DOI:10.3987/COM-95-S76