Technology Process of (R)-(E)-1,2,3,4,5-pentafluoro-6-(5-methyl-3-hexen-2-yl)benzene
There total 4 articles about (R)-(E)-1,2,3,4,5-pentafluoro-6-(5-methyl-3-hexen-2-yl)benzene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
copper(l) chloride; lithium tert-butoxide;
In
tetrahydrofuran;
at 40 ℃;
for 10h;
optical yield given as %ee;
enantioselective reaction;
Inert atmosphere;
DOI:10.1002/anie.201200809
- Guidance literature:
-
Multi-step reaction with 4 steps
1: isopropyl alcohol; potassium hydroxide / 48 h / 20 °C / Inert atmosphere
2: bis(cyclopentadienyl)titanium dichloride; isobutylmagnesium bromide / diethyl ether / 12 h / 0 - 20 °C / Inert atmosphere
3: pyridine; dmap / 1 h / 20 °C / Inert atmosphere
4: copper(l) chloride; lithium tert-butoxide / tetrahydrofuran / 10 h / 40 °C / Inert atmosphere
With
pyridine; dmap; bis(cyclopentadienyl)titanium dichloride; isobutylmagnesium bromide; isopropyl alcohol; copper(l) chloride; potassium hydroxide; lithium tert-butoxide;
In
tetrahydrofuran; diethyl ether;
DOI:10.1002/anie.201200809
- Guidance literature:
-
Multi-step reaction with 3 steps
1: bis(cyclopentadienyl)titanium dichloride; isobutylmagnesium bromide / diethyl ether / 12 h / 0 - 20 °C / Inert atmosphere
2: pyridine; dmap / 1 h / 20 °C / Inert atmosphere
3: copper(l) chloride; lithium tert-butoxide / tetrahydrofuran / 10 h / 40 °C / Inert atmosphere
With
pyridine; dmap; bis(cyclopentadienyl)titanium dichloride; isobutylmagnesium bromide; copper(l) chloride; lithium tert-butoxide;
In
tetrahydrofuran; diethyl ether;
DOI:10.1002/anie.201200809
