(6R,7S)-7-(tert-Butyl-dimethyl-silanyloxymethyl)-9-(4-methoxy-benzyloxymethyl)-8-methyl-1-oxo-2-aza-spiro[5.5]undec-8-ene-2-carboxylic acid benzyl ester

Base Information

Chemical Name:(6R,7S)-7-(tert-Butyl-dimethyl-silanyloxymethyl)-9-(4-methoxy-benzyloxymethyl)-8-methyl-1-oxo-2-aza-spiro[5.5]undec-8-ene-2-carboxylic acid benzyl ester
CAS No.:440677-04-3
Molecular Formula:C₃₅H₄₉NO₆Si
Molecular Weight:607.863
Hs Code.:

(6R,7S)-7-(tert-Butyl-dimethyl-silanyloxymethyl)-9-(4-methoxy-benzyloxymethyl)-8-methyl-1-oxo-2-aza-spiro[5.5]undec-8-ene-2-carboxylic acid benzyl ester

Synonyms:(6R,7S)-7-(tert-Butyl-dimethyl-silanyloxymethyl)-9-(4-methoxy-benzyloxymethyl)-8-methyl-1-oxo-2-aza-spiro[5.5]undec-8-ene-2-carboxylic acid benzyl ester

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Chemical Property of (6R,7S)-7-(tert-Butyl-dimethyl-silanyloxymethyl)-9-(4-methoxy-benzyloxymethyl)-8-methyl-1-oxo-2-aza-spiro[5.5]undec-8-ene-2-carboxylic acid benzyl ester

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Technology Process of (6R,7S)-7-(tert-Butyl-dimethyl-silanyloxymethyl)-9-(4-methoxy-benzyloxymethyl)-8-methyl-1-oxo-2-aza-spiro[5.5]undec-8-ene-2-carboxylic acid benzyl ester

There total 4 articles about (6R,7S)-7-(tert-Butyl-dimethyl-silanyloxymethyl)-9-(4-methoxy-benzyloxymethyl)-8-methyl-1-oxo-2-aza-spiro[5.5]undec-8-ene-2-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 440677-00-9
3-methylene-2-oxo-piperidine-1-carboxylic acid benzyl ester

: tert-butyl-[4-(4-methoxy-benzyloxymethyl)-3-methyl-penta-2,4-dienyloxy]-dimethyl-silane

: 440677-04-3
(6R,7S)-7-(tert-Butyl-dimethyl-silanyloxymethyl)-9-(4-methoxy-benzyloxymethyl)-8-methyl-1-oxo-2-aza-spiro[5.5]undec-8-ene-2-carboxylic acid benzyl ester

: (6S,7R)-7-(tert-Butyl-dimethyl-silanyloxymethyl)-9-(4-methoxy-benzyloxymethyl)-8-methyl-1-oxo-2-aza-spiro[5.5]undec-8-ene-2-carboxylic acid benzyl ester

: (6R,7R)-7-(tert-Butyl-dimethyl-silanyloxymethyl)-9-(4-methoxy-benzyloxymethyl)-8-methyl-1-oxo-2-aza-spiro[5.5]undec-8-ene-2-carboxylic acid benzyl ester

Guidance literature:: With 3 A molecular sieve; (-)-siam*Cu(SbF₆)2; In dichloromethane; at 25 ℃; for 24h; Title compound not separated from byproducts;
DOI:10.1055/s-2002-20450

Reference yield:

: 106412-35-5
N-benzyloxycarbonyl-2-piperidone

: 440677-04-3
(6R,7S)-7-(tert-Butyl-dimethyl-silanyloxymethyl)-9-(4-methoxy-benzyloxymethyl)-8-methyl-1-oxo-2-aza-spiro[5.5]undec-8-ene-2-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: i-Pr₂NEt / CH₂Cl₂ / 2 h / 25 °C

2.1: CH₂Cl₂ / 12 h / 25 °C

2.2: MeI / tetrahydrofuran / 2 h / 25 °C

3.1: 3 Angstroem molecular sieves / (-)-siam*Cu(SbF₆)2 / CH₂Cl₂ / 24 h / 25 °C

With 3 A molecular sieve; N-ethyl-N,N-diisopropylamine; (-)-siam*Cu(SbF₆)2; In dichloromethane; 3.1: asymmetric Diels-Alder reaction;
DOI:10.1055/s-2002-20450

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 440677-04-3
(6R,7S)-7-(tert-Butyl-dimethyl-silanyloxymethyl)-9-(4-methoxy-benzyloxymethyl)-8-methyl-1-oxo-2-aza-spiro[5.5]undec-8-ene-2-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 89 percent / NaH / tetrahydrofuran / 5 h / 25 °C

2.1: i-Pr₂NEt / CH₂Cl₂ / 2 h / 25 °C

3.1: CH₂Cl₂ / 12 h / 25 °C

3.2: MeI / tetrahydrofuran / 2 h / 25 °C

4.1: 3 Angstroem molecular sieves / (-)-siam*Cu(SbF₆)2 / CH₂Cl₂ / 24 h / 25 °C

With 3 A molecular sieve; sodium hydride; N-ethyl-N,N-diisopropylamine; (-)-siam*Cu(SbF₆)2; In tetrahydrofuran; dichloromethane; 4.1: asymmetric Diels-Alder reaction;
DOI:10.1055/s-2002-20450