C₅₄H₇₀O₉Si₂

Base Information

• Chemical Name: C₅₄H₇₀O₉Si₂
• CAS No.: 1018988-63-0
• Molecular Formula: C₅₄H₇₀O₉Si₂
• Molecular Weight: 919.315
• Mol file: 1018988-63-0.mol

Synonyms:C₅₄H₇₀O₉Si₂

Chemical Property of C₅₄H₇₀O₉Si₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₅₄H₇₀O₉Si₂

There total 10 articles about C₅₄H₇₀O₉Si₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

C52H68O8Si2 (1018988-48-1) + acetic anhydride (108-24-7) → C54H70O9Si2 (1018988-63-0)

Guidance literature:

With dmap; In pyridine; dichloromethane; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1002/asia.200800429

Reference yield:

C52H66O7Si2 (1018988-59-4) → C54H70O9Si2 (1018988-63-0)

Guidance literature:

Multi-step reaction with 10 steps

1.1: sodium tetrahydroborate / ethanol / 2 h / -78 °C / Inert atmosphere

2.1: dichloromethane / 1 h / 20 °C / Inert atmosphere; Molecular sieve

2.2: 39 h / 20 °C / Inert atmosphere

3.1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

4.1: 2,6-di-tert-butyl-4-methylpyridine; 2,3-dicyano-5,6-dichloro-p-benzoquinone / acetonitrile / 20 °C / Inert atmosphere

5.1: sodium tetrahydroborate / tetrahydrofuran; ethanol / -40 - -30 °C / Inert atmosphere

6.1: sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 24 h / 13 °C / Inert atmosphere

7.1: lithium borohydride / tetrahydrofuran / Inert atmosphere; Reflux

7.2: 4 h / 20 °C / Inert atmosphere

8.1: lithium borohydride / tetrahydrofuran / 26.5 h / 20 °C / Inert atmosphere; Reflux

8.2: 4 h / 20 °C / Inert atmosphere

9.1: water; acetic acid / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

10.1: dmap / pyridine; dichloromethane / 24 h / 20 °C / Inert atmosphere

With dmap; sodium tetrahydroborate; lithium borohydride; 2,6-di-tert-butyl-4-methylpyridine; water; sodium hydrogencarbonate; acetic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; pyridine; ethanol; dichloromethane; acetonitrile; 5.1: Luche reduction;

DOI:10.1002/asia.200800429

Reference yield:

C58H78O7Si3 (1018988-60-7) → C54H70O9Si2 (1018988-63-0)

Guidance literature:

Multi-step reaction with 7 steps

1.1: 2,6-di-tert-butyl-4-methylpyridine; 2,3-dicyano-5,6-dichloro-p-benzoquinone / acetonitrile / 20 °C / Inert atmosphere

2.1: sodium tetrahydroborate / tetrahydrofuran; ethanol / -40 - -30 °C / Inert atmosphere

3.1: sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 24 h / 13 °C / Inert atmosphere

4.1: lithium borohydride / tetrahydrofuran / Inert atmosphere; Reflux

4.2: 4 h / 20 °C / Inert atmosphere

5.1: lithium borohydride / tetrahydrofuran / 26.5 h / 20 °C / Inert atmosphere; Reflux

5.2: 4 h / 20 °C / Inert atmosphere

6.1: water; acetic acid / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

7.1: dmap / pyridine; dichloromethane / 24 h / 20 °C / Inert atmosphere

With dmap; sodium tetrahydroborate; lithium borohydride; 2,6-di-tert-butyl-4-methylpyridine; water; sodium hydrogencarbonate; acetic acid; 3-chloro-benzenecarboperoxoic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; pyridine; ethanol; dichloromethane; acetonitrile; 2.1: Luche reduction;

DOI:10.1002/asia.200800429

upstream raw materials:

C₅₂H₆₈O₈Si₂

acetic anhydride

C₅₂H₆₆O₇Si₂

C₅₂H₆₈O₇Si₂

Downstream raw materials:

C₃₈H₅₂O₉Si

C₅₀H₆₄O₁₂Si

C₃₇H₄₆O₁₃

C₃₅H₄₆O₁₃

Refernces

• 1、 Zhang, Hongxing,Sridhar Reddy, Maddi,Phoenix, Serge,Deslongchamps, Pierre. "Total synthesis of ouabagenin and ouabain". . p. 1272 - 1275. Retrieved 2008/12/22.