1,5-Diazocin-2(1H)-one,1-[4-[hexahydro-4- (2-hydroxyheptyl)-5-methyl-2-oxo-1,5- diazocin-1(2H)-yl]butyl]hexahydro-5-methyl- 4-phenyl-

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Chemical Name:1,5-Diazocin-2(1H)-one,1-[4-[hexahydro-4- (2-hydroxyheptyl)-5-methyl-2-oxo-1,5- diazocin-1(2H)-yl]butyl]hexahydro-5-methyl- 4-phenyl-
CAS No.:49620-05-5
Molecular Formula:C₃₁H₅₂N₄O₃
Molecular Weight:528.779
Hs Code.:
Mol file:49620-05-5.mol

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Chemical Property of 1,5-Diazocin-2(1H)-one,1-[4-[hexahydro-4- (2-hydroxyheptyl)-5-methyl-2-oxo-1,5- diazocin-1(2H)-yl]butyl]hexahydro-5-methyl- 4-phenyl-

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Technology Process of 1,5-Diazocin-2(1H)-one,1-[4-[hexahydro-4- (2-hydroxyheptyl)-5-methyl-2-oxo-1,5- diazocin-1(2H)-yl]butyl]hexahydro-5-methyl- 4-phenyl-

There total 32 articles about 1,5-Diazocin-2(1H)-one,1-[4-[hexahydro-4- (2-hydroxyheptyl)-5-methyl-2-oxo-1,5- diazocin-1(2H)-yl]butyl]hexahydro-5-methyl- 4-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1403934-31-5
(R,R)-4-(2′-hydroxyheptyl)-N(5)-methyl-1,5-diazocan-2-one

: 1403934-35-9
(S)-N(1)-(4′-bromobutyl)-4-phenyl-N(5)-methyl-1,5-diazocan-2-one

: 49620-05-5
(4′S,4''R,2'''R)-1-[2'-oxo-4′-phenyl-N(5')-methyl-1',5'-diazocan-N(1′)-yl]-4-[2''-oxo-4''-(2'''-hydroxyheptyl)-N(5'')-methyl-1'',5''-diazocan-N(1'')-yl]butane

Guidance literature:: With N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate; potassium hydroxide; In dimethyl sulfoxide; at 20 ℃; for 48h;
DOI:10.1021/jo301830j

Reference yield:

: 109742-04-3
4-(2-oxoheptyl)azetidin-2-one

: 49620-05-5,109835-94-1
hopromalinol

Guidance literature:: Multi-step reaction with 8 steps

1: 93 percent / NaBH₄ / methanol / 1 h / 0 °C

2: 1.) BuLi, 2.) BuLi, copper(I) iodide / 1.) THF, hexane, 0 deg C to RT, 6 h, 2.) THF, hexane, 0 deg C to RT, 16 h

3: 77 percent / KOH / tetrabutylammonium hydrogen sulfate / tetrahydrofuran / 84 h / Ambient temperature

4: 79 percent / NH₃ liq. / 312 h

5: acetonitrile; H₂O / 0.08 h / Ambient temperature

6: NaBH₃CN, AcOH / acetonitrile; H₂O / 1 h

7: 1.) potassium bis(trimethylsilyl)amide, 3.) NaH / 1.) THF, toluene, 0 deg C, 30 min, 2.) THF, toluene, 20 deg C, 24 h, 3.)THF, toluene, 20 deg C, 17 d

8: 91 percent / H₂, conc. aq. HCl / Pt / methanol / 3 h / 1 Torr / Ambient temperature

With hydrogenchloride; potassium hydroxide; sodium tetrahydroborate; copper(l) iodide; n-butyllithium; ammonia; hydrogen; potassium hexamethylsilazane; sodium hydride; sodium cyanoborohydride; acetic acid; tetra(n-butyl)ammonium hydrogensulfate; platinum; In tetrahydrofuran; methanol; water; acetonitrile;

Reference yield:

: 109742-06-5
4-(2-hydroxyheptyl)azetidin-2-one

: 49620-05-5,109835-94-1
hopromalinol

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) BuLi, 2.) BuLi, copper(I) iodide / 1.) THF, hexane, 0 deg C to RT, 6 h, 2.) THF, hexane, 0 deg C to RT, 16 h

2: 77 percent / KOH / tetrabutylammonium hydrogen sulfate / tetrahydrofuran / 84 h / Ambient temperature

3: 79 percent / NH₃ liq. / 312 h

4: acetonitrile; H₂O / 0.08 h / Ambient temperature

5: NaBH₃CN, AcOH / acetonitrile; H₂O / 1 h

6: 1.) potassium bis(trimethylsilyl)amide, 3.) NaH / 1.) THF, toluene, 0 deg C, 30 min, 2.) THF, toluene, 20 deg C, 24 h, 3.)THF, toluene, 20 deg C, 17 d

7: 91 percent / H₂, conc. aq. HCl / Pt / methanol / 3 h / 1 Torr / Ambient temperature

With hydrogenchloride; potassium hydroxide; copper(l) iodide; n-butyllithium; ammonia; hydrogen; potassium hexamethylsilazane; sodium hydride; sodium cyanoborohydride; acetic acid; tetra(n-butyl)ammonium hydrogensulfate; platinum; In tetrahydrofuran; methanol; water; acetonitrile;