3-[4-(3-Chloro-phenyl)-piperazin-1-yl]-N-(7-hydroxy-2,2,4,6-tetramethyl-indan-1-yl)-propionamide

Base Information

Chemical Name:3-[4-(3-Chloro-phenyl)-piperazin-1-yl]-N-(7-hydroxy-2,2,4,6-tetramethyl-indan-1-yl)-propionamide
CAS No.:103247-06-9
Molecular Formula:C₂₆H₃₄ClN₃O₂
Molecular Weight:456.028
Hs Code.:

Synonyms:3-[4-(3-Chloro-phenyl)-piperazin-1-yl]-N-(7-hydroxy-2,2,4,6-tetramethyl-indan-1-yl)-propionamide

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Chemical Property of 3-[4-(3-Chloro-phenyl)-piperazin-1-yl]-N-(7-hydroxy-2,2,4,6-tetramethyl-indan-1-yl)-propionamide

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Technology Process of 3-[4-(3-Chloro-phenyl)-piperazin-1-yl]-N-(7-hydroxy-2,2,4,6-tetramethyl-indan-1-yl)-propionamide

There total 2 articles about 3-[4-(3-Chloro-phenyl)-piperazin-1-yl]-N-(7-hydroxy-2,2,4,6-tetramethyl-indan-1-yl)-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 133794-96-4
1-<(3-chloropropionyl)amino>-7-hydroxy-2,2,4,6-tetramethylindan

: 13078-15-4,51639-49-7,65369-76-8
1-(3-chlorophenyl)piperazine hydrochloride

: 103247-06-9
3-[4-(3-Chloro-phenyl)-piperazin-1-yl]-N-(7-hydroxy-2,2,4,6-tetramethyl-indan-1-yl)-propionamide

Guidance literature:: With triethylamine; In acetonitrile; for 2h; Heating;
DOI:10.1021/jm00111a013

Reference yield:

: 93747-39-8
1-Amino-7-hydroxy-2,2,4,6-tetramethylindane

: 103247-06-9
3-[4-(3-Chloro-phenyl)-piperazin-1-yl]-N-(7-hydroxy-2,2,4,6-tetramethyl-indan-1-yl)-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / Et₃N / CHCl₃ / 2 h / 0 °C

2: 86 percent / Et₃N / acetonitrile / 2 h / Heating

With triethylamine; In chloroform; acetonitrile;
DOI:10.1021/jm00111a013