(2Z,5Z)-2-[5-(4-chlorobenzylidene)-4-oxo-3-phenyl-thiazolidin-2-ylidene]-2-cyano-N-(4-methylphenyl)acetamide

Base Information

• Chemical Name: (2Z,5Z)-2-[5-(4-chlorobenzylidene)-4-oxo-3-phenyl-thiazolidin-2-ylidene]-2-cyano-N-(4-methylphenyl)acetamide
• CAS No.: 1357291-35-0
• Molecular Formula: C₂₆H₁₈ClN₃O₂S
• Molecular Weight: 471.967

Synonyms:(2Z,5Z)-2-[5-(4-chlorobenzylidene)-4-oxo-3-phenyl-thiazolidin-2-ylidene]-2-cyano-N-(4-methylphenyl)acetamide

Chemical Property of (2Z,5Z)-2-[5-(4-chlorobenzylidene)-4-oxo-3-phenyl-thiazolidin-2-ylidene]-2-cyano-N-(4-methylphenyl)acetamide

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Technology Process of (2Z,5Z)-2-[5-(4-chlorobenzylidene)-4-oxo-3-phenyl-thiazolidin-2-ylidene]-2-cyano-N-(4-methylphenyl)acetamide

There total 4 articles about (2Z,5Z)-2-[5-(4-chlorobenzylidene)-4-oxo-3-phenyl-thiazolidin-2-ylidene]-2-cyano-N-(4-methylphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

(Z)-2-cyano-N-(4-methylphenyl)-2-(4-oxo-3-phenyl-thiazolidin-2-ylidene)acetamide (1357291-27-0) + 4-chlorobenzaldehyde (104-88-1) → (2Z,5Z)-2-[5-(4-chlorobenzylidene)-4-oxo-3-phenyl-thiazolidin-2-ylidene]-2-cyano-N-(4-methylphenyl)acetamide (1357291-35-0)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 6h;

DOI:10.1016/j.ejmech.2011.11.006

Reference yield:

2-cyano-3-mercapto-N-(4-methylphenyl)-3-phenylaminoacrylamide (1357291-25-8) → (2Z,5Z)-2-[5-(4-chlorobenzylidene)-4-oxo-3-phenyl-thiazolidin-2-ylidene]-2-cyano-N-(4-methylphenyl)acetamide (1357291-35-0)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran / 20 °C

2: triethylamine / N,N-dimethyl-formamide / 6 h / 20 °C

With triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2011.11.006

Reference yield:

2-cyano-N-(4-methylphenyl)acetamide (6876-54-6) → (2Z,5Z)-2-[5-(4-chlorobenzylidene)-4-oxo-3-phenyl-thiazolidin-2-ylidene]-2-cyano-N-(4-methylphenyl)acetamide (1357291-35-0)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium hydroxide / tetrahydrofuran / 48 h / 20 °C

2: triethylamine / tetrahydrofuran / 20 °C

3: triethylamine / N,N-dimethyl-formamide / 6 h / 20 °C

With triethylamine; potassium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2011.11.006

upstream raw materials:

2-cyano-3-mercapto-N-(4-methylphenyl)-3-phenylaminoacrylamide

(Z)-2-cyano-N-(4-methylphenyl)-2-(4-oxo-3-phenyl-thiazolidin-2-ylidene)acetamide

4-chlorobenzaldehyde

2-cyano-N-(4-methylphenyl)acetamide

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