4-bromo-N-(3-(5-(3-hydroxybenzoyl)thiophene-2-yl)phenyl)-2-trifluoromethoxybenzenesulfonamide

Base Information

Chemical Name:4-bromo-N-(3-(5-(3-hydroxybenzoyl)thiophene-2-yl)phenyl)-2-trifluoromethoxybenzenesulfonamide
CAS No.:1361252-71-2
Molecular Formula:C₂₄H₁₅BrF₃NO₅S₂
Molecular Weight:598.418
Hs Code.:

Synonyms:4-bromo-N-(3-(5-(3-hydroxybenzoyl)thiophene-2-yl)phenyl)-2-trifluoromethoxybenzenesulfonamide

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Chemical Property of 4-bromo-N-(3-(5-(3-hydroxybenzoyl)thiophene-2-yl)phenyl)-2-trifluoromethoxybenzenesulfonamide

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Technology Process of 4-bromo-N-(3-(5-(3-hydroxybenzoyl)thiophene-2-yl)phenyl)-2-trifluoromethoxybenzenesulfonamide

There total 5 articles about 4-bromo-N-(3-(5-(3-hydroxybenzoyl)thiophene-2-yl)phenyl)-2-trifluoromethoxybenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 175278-14-5
4-bromo-2-(trifluoromethoxy)benzene-1-sulfonyl chloride

: (5-(3-aminophenyl)thiophene-2-yl)(3-hydroxyphenyl)methanone

: 1361252-71-2
4-bromo-N-(3-(5-(3-hydroxybenzoyl)thiophene-2-yl)phenyl)-2-trifluoromethoxybenzenesulfonamide

Guidance literature:: With pyridine; at 20 ℃;

Reference yield:

: (5-(3-aminophenyl)-thiophene-2-yl)(3-ethoxy-2,6-difluorophenyl)methanone

: 1361252-71-2
4-bromo-N-(3-(5-(3-hydroxybenzoyl)thiophene-2-yl)phenyl)-2-trifluoromethoxybenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: boron tribromide / dichloromethane / -78 - 20 °C / Inert atmosphere

2: pyridine / 20 °C

With pyridine; boron tribromide; In dichloromethane;
DOI:10.1016/j.ejmech.2015.08.030

Reference yield:

: (5-bromothiophene-2-yl)-(3-ethoxy-2,6-difluorophenyl)methanone

: 1361252-71-2
4-bromo-N-(3-(5-(3-hydroxybenzoyl)thiophene-2-yl)phenyl)-2-trifluoromethoxybenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / Reflux; Inert atmosphere

2: boron tribromide / dichloromethane / -78 - 20 °C / Inert atmosphere

3: pyridine / 20 °C

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; boron tribromide; caesium carbonate; In 1,2-dimethoxyethane; dichloromethane; water; 1: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2015.08.030