4-{3-[4-(4-Hydroxyphenyl)phenyl]propanoyl}amino-1-methylpyrrole-3-carboxylic acid

Base Information

Chemical Name:4-{3-[4-(4-Hydroxyphenyl)phenyl]propanoyl}amino-1-methylpyrrole-3-carboxylic acid
CAS No.:1204422-11-6
Molecular Formula:C₂₁H₂₀N₂O₄
Molecular Weight:364.401
Hs Code.:

Synonyms:4-{3-[4-(4-Hydroxyphenyl)phenyl]propanoyl}amino-1-methylpyrrole-3-carboxylic acid

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Chemical Property of 4-{3-[4-(4-Hydroxyphenyl)phenyl]propanoyl}amino-1-methylpyrrole-3-carboxylic acid

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Technology Process of 4-{3-[4-(4-Hydroxyphenyl)phenyl]propanoyl}amino-1-methylpyrrole-3-carboxylic acid

There total 8 articles about 4-{3-[4-(4-Hydroxyphenyl)phenyl]propanoyl}amino-1-methylpyrrole-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1204423-25-5
4-{3-[4-(4-methoxyphenyl)phenyl]propanoyl}amino-1-methylpyrrole-3-carboxylic acid

: 1204422-11-6
4-{3-[4-(4-Hydroxyphenyl)phenyl]propanoyl}amino-1-methylpyrrole-3-carboxylic acid

Guidance literature:: 4-{3-[4-(4-methoxyphenyl)phenyl]propanoyl}amino-1-methylpyrrole-3-carboxylic acid; With boron tribromide; In dichloromethane; at -78 - 20 ℃; for 1h; Inert atmosphere;

With water; In dichloromethane; at -78 - 20 ℃;

Reference yield:

: 104-92-7
1-bromo-4-methoxy-benzene

: 1204422-11-6
4-{3-[4-(4-Hydroxyphenyl)phenyl]propanoyl}amino-1-methylpyrrole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 8 h / 80 °C

2.1: sodium hydroxide; water / ethanol / 2 h / 20 °C

3.1: triethylamine; HATU / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere; Cooling with ice

4.1: water; lithium hydroxide / tetrahydrofuran; methanol / 3 h / 70 °C

5.1: boron tribromide / dichloromethane / 1 h / -78 - 20 °C / Inert atmosphere

5.2: -78 - 20 °C

With water; boron tribromide; sodium carbonate; triethylamine; HATU; sodium hydroxide; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 660440-57-3
(4-(3-ethoxy-3-oxopropyl)phenyl)boronic acid

: 1204422-11-6
4-{3-[4-(4-Hydroxyphenyl)phenyl]propanoyl}amino-1-methylpyrrole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 8 h / 80 °C

2.1: sodium hydroxide; water / ethanol / 2 h / 20 °C

3.1: triethylamine; HATU / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere; Cooling with ice

4.1: water; lithium hydroxide / tetrahydrofuran; methanol / 3 h / 70 °C

5.1: boron tribromide / dichloromethane / 1 h / -78 - 20 °C / Inert atmosphere

5.2: -78 - 20 °C

With water; boron tribromide; sodium carbonate; triethylamine; HATU; sodium hydroxide; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;