4-{2-(2-carboxy-ethyl)-3-[6-(3-dimethylcarbamoyl-5-thiophen-3-yl-phenoxy)-hexyl]-phenoxy}-butyric acid

Base Information

Chemical Name:4-{2-(2-carboxy-ethyl)-3-[6-(3-dimethylcarbamoyl-5-thiophen-3-yl-phenoxy)-hexyl]-phenoxy}-butyric acid
CAS No.:1162260-91-4
Molecular Formula:C₃₂H₃₉NO₇S
Molecular Weight:581.73
Hs Code.:

Synonyms:4-{2-(2-carboxy-ethyl)-3-[6-(3-dimethylcarbamoyl-5-thiophen-3-yl-phenoxy)-hexyl]-phenoxy}-butyric acid

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Chemical Property of 4-{2-(2-carboxy-ethyl)-3-[6-(3-dimethylcarbamoyl-5-thiophen-3-yl-phenoxy)-hexyl]-phenoxy}-butyric acid

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Technology Process of 4-{2-(2-carboxy-ethyl)-3-[6-(3-dimethylcarbamoyl-5-thiophen-3-yl-phenoxy)-hexyl]-phenoxy}-butyric acid

There total 19 articles about 4-{2-(2-carboxy-ethyl)-3-[6-(3-dimethylcarbamoyl-5-thiophen-3-yl-phenoxy)-hexyl]-phenoxy}-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₆H₄₇NO₇S

: 1162260-91-4
4-{2-(2-carboxy-ethyl)-3-[6-(3-dimethylcarbamoyl-5-thiophen-3-yl-phenoxy)-hexyl]-phenoxy}-butyric acid

Guidance literature:: C₃₆H₄₇NO₇S; With water; sodium hydroxide; In ethanol; at 20 ℃; for 3h;

With hydrogenchloride; In ethanol; water; Acidic aqueous solution;

Reference yield:

: 56359-23-0
4-(2,3-dimethylphenoxy)butyric acid ethyl ester

: 1162260-91-4
4-{2-(2-carboxy-ethyl)-3-[6-(3-dimethylcarbamoyl-5-thiophen-3-yl-phenoxy)-hexyl]-phenoxy}-butyric acid

Guidance literature:: Multi-step reaction with 13 steps

1.1: dipotassium peroxodisulfate; copper(ll) sulfate pentahydrate / water; acetonitrile / 0.67 h / Heating / reflux

2.1: sodium ethanolate / ethanol / 48 h / 20 °C

3.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / chlorobenzene / 1 h / 20 - 85 °C

4.1: acetonitrile / 1 h / Heating / reflux; Inert atmosphere

5.1: ethyloxirane; acetonitrile / 15 h / Heating / reflux

6.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 36 h / 20 °C / 760.05 Torr

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 0 - 20 °C

8.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 3 h / 0 - 10 °C

9.1: potassium carbonate / N,N-dimethyl-formamide; acetone / 24 h / 70 °C

10.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 5 h / 78 °C

11.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

12.1: N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / dichloromethane; N,N-dimethyl-formamide / 4 h / 20 °C

13.1: water; sodium hydroxide / ethanol / 3 h / 20 °C

13.2: Acidic aqueous solution

With dipotassium peroxodisulfate; N-Bromosuccinimide; copper(ll) sulfate pentahydrate; 2,2'-azobis(isobutyronitrile); carbon tetrabromide; tetrabutyl ammonium fluoride; water; hydrogen; sodium ethanolate; potassium carbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; trifluoroacetic acid; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; ethyloxirane; 1,2-dimethoxyethane; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; chlorobenzene; acetone; acetonitrile; 2.1: Horner-Wadsworth-Emmons Olefination / 4.1: Wittig Reaction / 5.1: Wittig Reaction / 10.1: Suzuki Coupling;

Reference yield:

: 1123157-53-8
4-(2-formyl-3-methylphenoxy)butyric acid ethyl ester

: 1162260-91-4
4-{2-(2-carboxy-ethyl)-3-[6-(3-dimethylcarbamoyl-5-thiophen-3-yl-phenoxy)-hexyl]-phenoxy}-butyric acid

Guidance literature:: Multi-step reaction with 12 steps

1.1: sodium ethanolate / ethanol / 48 h / 20 °C

2.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / chlorobenzene / 1 h / 20 - 85 °C

3.1: acetonitrile / 1 h / Heating / reflux; Inert atmosphere

4.1: ethyloxirane; acetonitrile / 15 h / Heating / reflux

5.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 36 h / 20 °C / 760.05 Torr

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 0 - 20 °C

7.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 3 h / 0 - 10 °C

8.1: potassium carbonate / N,N-dimethyl-formamide; acetone / 24 h / 70 °C

9.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 5 h / 78 °C

10.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

11.1: N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / dichloromethane; N,N-dimethyl-formamide / 4 h / 20 °C

12.1: water; sodium hydroxide / ethanol / 3 h / 20 °C

12.2: Acidic aqueous solution

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); carbon tetrabromide; tetrabutyl ammonium fluoride; water; hydrogen; sodium ethanolate; potassium carbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; trifluoroacetic acid; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; ethyloxirane; 1,2-dimethoxyethane; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; chlorobenzene; acetone; acetonitrile; 1.1: Horner-Wadsworth-Emmons Olefination / 3.1: Wittig Reaction / 4.1: Wittig Reaction / 9.1: Suzuki Coupling;