[(4Z)-4-benzylidene-5-oxo-2-phenyl-4,5-dihydro-1H-imidazol-1-yl]acetic acid

Base Information

• Chemical Name: [(4Z)-4-benzylidene-5-oxo-2-phenyl-4,5-dihydro-1H-imidazol-1-yl]acetic acid
• CAS No.: 99875-16-8
• Molecular Formula: C₁₈H₁₄N₂O₃
• Molecular Weight: 306.321
• Mol file: 99875-16-8.mol

Synonyms:[(4Z)-4-benzylidene-5-oxo-2-phenyl-4,5-dihydro-1H-imidazol-1-yl]acetic acid

Chemical Property of [(4Z)-4-benzylidene-5-oxo-2-phenyl-4,5-dihydro-1H-imidazol-1-yl]acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(4Z)-4-benzylidene-5-oxo-2-phenyl-4,5-dihydro-1H-imidazol-1-yl]acetic acid

There total 6 articles about [(4Z)-4-benzylidene-5-oxo-2-phenyl-4,5-dihydro-1H-imidazol-1-yl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

{[(2Z)-2-benzamido-3-phenylprop-2-enoyl]amino}acetic acid (99875-12-4) → [(4Z)-4-benzylidene-5-oxo-2-phenyl-4,5-dihydro-1H-imidazol-1-yl]acetic acid (99875-16-8)

Guidance literature:

With 1,1,1,3,3,3-hexamethyl-disilazane; In N,N-dimethyl-formamide; for 1h; Reagent/catalyst; Reflux;

DOI:10.1134/S1070428018090178

Reference yield: 64.0%

4-benzylidene-2-phenyloxazole-5(4H)-one (842-74-0,5839-91-8) + glycine (56-40-6,18875-39-3,25718-94-9) → [(4Z)-4-benzylidene-5-oxo-2-phenyl-4,5-dihydro-1H-imidazol-1-yl]acetic acid (99875-16-8)

Guidance literature:

at 150 ℃; for 1h;

Reference yield:

N-n-butyl-2-benzoylaminocinnamide (99875-10-2) → [(4Z)-4-benzylidene-5-oxo-2-phenyl-4,5-dihydro-1H-imidazol-1-yl]acetic acid (99875-16-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 4 percent / sodium acetate / acetic acid / 4 h / Heating

2: acetic acid

With sodium acetate; acetic acid; In acetic acid;

upstream raw materials:

(4-benzylidene-5-oxo-2-phenyl-4,5-dihydro-imidazol-1-yl)-acetic acid ethyl ester

aniline

(4Z)-4-benzylidene-2-phenyl-1,3-oxazol-5(4H)-one

4-benzylidene-2-phenyloxazole-5(4H)-one

Downstream raw materials:

4-benzylidene-2-phenyl-5-imidazolone-acetyl chloride

4-Nitro-benzoic acid N'-(2-{5-oxo-2-phenyl-4-[1-phenyl-meth-(Z)-ylidene]-4,5-dihydro-imidazol-1-yl}-acetyl)-hydrazide

Benzoic acid N'-(2-{5-oxo-2-phenyl-4-[1-phenyl-meth-(Z)-ylidene]-4,5-dihydro-imidazol-1-yl}-acetyl)-hydrazide