(2S,6S,7S,9S,15R)-15-((S)-5-{(4S,6S)-6-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-4-methoxy-4-methyl-5,6-dihydro-4H-pyran-2-yl}-2-hydroxy-5-oxo-pentyl)-15-methyl-2,9-diphenyl-1,8,13,16-tetraoxa-dispiro[5.0.5.4]hexadecan-14-one

Base Information

Chemical Name:(2S,6S,7S,9S,15R)-15-((S)-5-{(4S,6S)-6-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-4-methoxy-4-methyl-5,6-dihydro-4H-pyran-2-yl}-2-hydroxy-5-oxo-pentyl)-15-methyl-2,9-diphenyl-1,8,13,16-tetraoxa-dispiro[5.0.5.4]hexadecan-14-one
CAS No.:220691-12-3
Molecular Formula:C₅₆H₇₀O₁₀Si
Molecular Weight:931.251
Hs Code.:

(2S,6S,7S,9S,15R)-15-((S)-5-{(4S,6S)-6-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-4-methoxy-4-methyl-5,6-dihydro-4H-pyran-2-yl}-2-hydroxy-5-oxo-pentyl)-15-methyl-2,9-diphenyl-1,8,13,16-tetraoxa-dispiro[5.0.5.4]hexadecan-14-one

Synonyms:(2S,6S,7S,9S,15R)-15-((S)-5-{(4S,6S)-6-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-4-methoxy-4-methyl-5,6-dihydro-4H-pyran-2-yl}-2-hydroxy-5-oxo-pentyl)-15-methyl-2,9-diphenyl-1,8,13,16-tetraoxa-dispiro[5.0.5.4]hexadecan-14-one

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Chemical Property of (2S,6S,7S,9S,15R)-15-((S)-5-{(4S,6S)-6-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-4-methoxy-4-methyl-5,6-dihydro-4H-pyran-2-yl}-2-hydroxy-5-oxo-pentyl)-15-methyl-2,9-diphenyl-1,8,13,16-tetraoxa-dispiro[5.0.5.4]hexadecan-14-one

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Technology Process of (2S,6S,7S,9S,15R)-15-((S)-5-{(4S,6S)-6-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-4-methoxy-4-methyl-5,6-dihydro-4H-pyran-2-yl}-2-hydroxy-5-oxo-pentyl)-15-methyl-2,9-diphenyl-1,8,13,16-tetraoxa-dispiro[5.0.5.4]hexadecan-14-one

There total 11 articles about (2S,6S,7S,9S,15R)-15-((S)-5-{(4S,6S)-6-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-4-methoxy-4-methyl-5,6-dihydro-4H-pyran-2-yl}-2-hydroxy-5-oxo-pentyl)-15-methyl-2,9-diphenyl-1,8,13,16-tetraoxa-dispiro[5.0.5.4]hexadecan-14-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 154859-09-3
(6S,6'S)-6,6'-Diphenyl-5,6,5',6'-tetrahydro-4H,4'H-[2,2']bipyranyl

: 220691-12-3
(2S,6S,7S,9S,15R)-15-((S)-5-{(4S,6S)-6-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-4-methoxy-4-methyl-5,6-dihydro-4H-pyran-2-yl}-2-hydroxy-5-oxo-pentyl)-15-methyl-2,9-diphenyl-1,8,13,16-tetraoxa-dispiro[5.0.5.4]hexadecan-14-one

Guidance literature:: Multi-step reaction with 9 steps

1: 89 percent / Ph₃P*HBr / CH₂Cl₂

2: 1.) LDA, DMPU, 2.) BuLi / 1.) THF, PhMe, -78 deg C, 2.) THF, PhMe

3: 1.) LDA, DMPU, 2.) BuLi / 1.) THF, DME, -78 deg C, 2.) THF, DME, -78 deg C to r.t.

4: 82 percent / K₂OsO₂(OH)4, (DHQD)2PYR, K₃Fe(CN)6, H₂O / 2-methyl-propan-2-ol / 0 °C

6: 1.) BuLi, CuCN, LiCl, 2.) BF₃*Et₂O / 1.) THF, -78 deg C, 2.) THF

7: 1.) BH₃*SMe₂, 2.) H₂O₂, phosphate buffer (pH 7) / 1.) THF, 2.) THF

8: 78 percent / TPAP, NMO, molecular sieves 4 Angstroem / CH₂Cl₂ / 0 °C

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; n-butyllithium; N-methyl-2-indolinone; phosphate buffer; tetrapropylammonium perruthennate; hydroquinindine-2,5-diphenyl-4,6-pyrimidinediyl diether; potassium dioxotetrahydroxoosmate(VI); dimethylsulfide borane complex; 4 A molecular sieve; boron trifluoride diethyl etherate; water; dihydrogen peroxide; triphenylphosphine hydrobromide; lithium chloride; potassium hexacyanoferrate(III); lithium diisopropyl amide; In dichloromethane; tert-butyl alcohol;

Reference yield:

: (S)-2-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,3-dihydro-pyran-4-one

: 220691-12-3
(2S,6S,7S,9S,15R)-15-((S)-5-{(4S,6S)-6-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-4-methoxy-4-methyl-5,6-dihydro-4H-pyran-2-yl}-2-hydroxy-5-oxo-pentyl)-15-methyl-2,9-diphenyl-1,8,13,16-tetraoxa-dispiro[5.0.5.4]hexadecan-14-one

Guidance literature:: Multi-step reaction with 3 steps

1: LiBr / tetrahydrofuran / -78 °C

2: 98 percent / Ag₂O

With lithium bromide; silver(l) oxide; In tetrahydrofuran;

Reference yield:

: 220690-96-0
(2S,6R,7S,9S)-2,9-Diphenyl-1,8,13,16-tetraoxa-dispiro[5.0.5.4]hexadecan-14-one

: 220691-12-3
(2S,6S,7S,9S,15R)-15-((S)-5-{(4S,6S)-6-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-4-methoxy-4-methyl-5,6-dihydro-4H-pyran-2-yl}-2-hydroxy-5-oxo-pentyl)-15-methyl-2,9-diphenyl-1,8,13,16-tetraoxa-dispiro[5.0.5.4]hexadecan-14-one

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) LDA, DMPU, 2.) BuLi / 1.) THF, PhMe, -78 deg C, 2.) THF, PhMe

2: 1.) LDA, DMPU, 2.) BuLi / 1.) THF, DME, -78 deg C, 2.) THF, DME, -78 deg C to r.t.

3: 82 percent / K₂OsO₂(OH)4, (DHQD)2PYR, K₃Fe(CN)6, H₂O / 2-methyl-propan-2-ol / 0 °C

5: 1.) BuLi, CuCN, LiCl, 2.) BF₃*Et₂O / 1.) THF, -78 deg C, 2.) THF

6: 1.) BH₃*SMe₂, 2.) H₂O₂, phosphate buffer (pH 7) / 1.) THF, 2.) THF

7: 78 percent / TPAP, NMO, molecular sieves 4 Angstroem / CH₂Cl₂ / 0 °C

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; n-butyllithium; N-methyl-2-indolinone; phosphate buffer; tetrapropylammonium perruthennate; hydroquinindine-2,5-diphenyl-4,6-pyrimidinediyl diether; potassium dioxotetrahydroxoosmate(VI); dimethylsulfide borane complex; 4 A molecular sieve; boron trifluoride diethyl etherate; water; dihydrogen peroxide; lithium chloride; potassium hexacyanoferrate(III); lithium diisopropyl amide; In dichloromethane; tert-butyl alcohol;