N-{(1-cyclohexyl-1H-tetrazol-5-yl)[4-(dimethylamino)phenyl]methyl}-3-(3-methyl-3H-diaziren-3-yl)-N-(2-propyn-1-yl)propanamide

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Chemical Name:N-{(1-cyclohexyl-1H-tetrazol-5-yl)[4-(dimethylamino)phenyl]methyl}-3-(3-methyl-3H-diaziren-3-yl)-N-(2-propyn-1-yl)propanamide
CAS No.:1620482-69-0
Molecular Formula:C₂₄H₃₂N₈O
Molecular Weight:448.571
Hs Code.:

Synonyms:N-{(1-cyclohexyl-1H-tetrazol-5-yl)[4-(dimethylamino)phenyl]methyl}-3-(3-methyl-3H-diaziren-3-yl)-N-(2-propyn-1-yl)propanamide

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Chemical Property of N-{(1-cyclohexyl-1H-tetrazol-5-yl)[4-(dimethylamino)phenyl]methyl}-3-(3-methyl-3H-diaziren-3-yl)-N-(2-propyn-1-yl)propanamide

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Technology Process of N-{(1-cyclohexyl-1H-tetrazol-5-yl)[4-(dimethylamino)phenyl]methyl}-3-(3-methyl-3H-diaziren-3-yl)-N-(2-propyn-1-yl)propanamide

There total 3 articles about N-{(1-cyclohexyl-1H-tetrazol-5-yl)[4-(dimethylamino)phenyl]methyl}-3-(3-methyl-3H-diaziren-3-yl)-N-(2-propyn-1-yl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1620483-27-3
4-[(1-cyclohexyl-1H-tetrazol-5-yl)(2-propyn-1-ylamino)methyl]-N,N-dimethylaniline

: 25055-86-1
3-(3-methyl-3H-diazirine-3-yl)propionic acid

: 1620482-69-0
N-{(1-cyclohexyl-1H-tetrazol-5-yl)[4-(dimethylamino)phenyl]methyl}-3-(3-methyl-3H-diaziren-3-yl)-N-(2-propyn-1-yl)propanamide

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 60 ℃; Inert atmosphere;
DOI:10.1021/ja505517t

Reference yield:

: 3128-06-1
5-ketohexanoic acid

: 1620482-69-0
N-{(1-cyclohexyl-1H-tetrazol-5-yl)[4-(dimethylamino)phenyl]methyl}-3-(3-methyl-3H-diaziren-3-yl)-N-(2-propyn-1-yl)propanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: ammonia / methanol / 0 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

1.3: 0 °C / Inert atmosphere

2.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 60 °C / Inert atmosphere

With 1-hydroxy-7-aza-benzotriazole; ammonia; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/ja505517t

Reference yield:

: 931-53-3
Cyclohexyl isocyanide

: 100-10-7
4-dimethylamino-benzaldehyde

: 1620482-69-0
N-{(1-cyclohexyl-1H-tetrazol-5-yl)[4-(dimethylamino)phenyl]methyl}-3-(3-methyl-3H-diaziren-3-yl)-N-(2-propyn-1-yl)propanamide

Guidance literature:: Multi-step reaction with 2 steps

1: trimethylsilylazide / methanol / 0 - 20 °C / Inert atmosphere

2: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 60 °C / Inert atmosphere

With 1-hydroxy-7-aza-benzotriazole; trimethylsilylazide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/ja505517t