3-methyl-2-(4'-(trifluoromethoxy)-[1,1'-biphenyl]-4-yl)quinolin-4(1H)-one

Base Information

Chemical Name:3-methyl-2-(4'-(trifluoromethoxy)-[1,1'-biphenyl]-4-yl)quinolin-4(1H)-one
CAS No.:1361967-73-8
Molecular Formula:C₂₃H₁₆F₃NO₂
Molecular Weight:395.381
Hs Code.:

Synonyms:3-methyl-2-(4'-(trifluoromethoxy)-[1,1'-biphenyl]-4-yl)quinolin-4(1H)-one

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Chemical Property of 3-methyl-2-(4'-(trifluoromethoxy)-[1,1'-biphenyl]-4-yl)quinolin-4(1H)-one

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Technology Process of 3-methyl-2-(4'-(trifluoromethoxy)-[1,1'-biphenyl]-4-yl)quinolin-4(1H)-one

There total 6 articles about 3-methyl-2-(4'-(trifluoromethoxy)-[1,1'-biphenyl]-4-yl)quinolin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1361967-63-6
2-(4-bromophenyl)-3-methylquinolin-4(1H)-one

: 139301-27-2
4-trifluoromethoxyphenylboronic acid

: 1361967-73-8
3-methyl-2-(4'-(trifluoromethoxy)-[1,1'-biphenyl]-4-yl)quinolin-4(1H)-one

Guidance literature:: With potassium carbonate; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; In 1,4-dioxane; at 100 ℃; for 24h; Inert atmosphere;

Reference yield: 60.0%

: 1361967-59-0
C₂₁H₂₁NO₃

: 139301-27-2
4-trifluoromethoxyphenylboronic acid

: 1361967-73-8
3-methyl-2-(4'-(trifluoromethoxy)-[1,1'-biphenyl]-4-yl)quinolin-4(1H)-one

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In 1,4-dioxane; at 100 ℃; for 24h; Inert atmosphere;
DOI:10.1021/jm201184h

Reference yield:

: 63478-10-4
2-(2'-anilinyl)-4,4-dimethyl-4,5-dihydro-1,3-oxazole

: 1361967-73-8
3-methyl-2-(4'-(trifluoromethoxy)-[1,1'-biphenyl]-4-yl)quinolin-4(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / butan-1-ol / 24 h / 130 °C / Inert atmosphere

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / 1,4-dioxane / 24 h / 100 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; toluene-4-sulfonic acid; In 1,4-dioxane; butan-1-ol; 2: Suzuki coupling;
DOI:10.1021/jm201184h