C₂₀H₁₅FN₂O₃

Base Information

• Chemical Name: C₂₀H₁₅FN₂O₃
• CAS No.: 1367127-58-9
• Molecular Formula: C₂₀H₁₅FN₂O₃
• Molecular Weight: 350.349
• Mol file: 1367127-58-9.mol

Synonyms:C₂₀H₁₅FN₂O₃

Chemical Property of C₂₀H₁₅FN₂O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₀H₁₅FN₂O₃

There total 8 articles about C₂₀H₁₅FN₂O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C20H13FN2O (1367127-56-7) → C20H15FN2O3 (1367127-58-9)

Guidance literature:

With AD-mix α; In water; tert-butyl alcohol; at 0 - 20 ℃; for 12h;

Reference yield:

2-Cyanopyridine (100-70-9,1232006-36-8) → C20H15FN2O3 (1367127-58-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: dihydrogen peroxide / methyltrioxorhenium(VII) / dichloromethane; water / 6 h / 20 °C

1.2: 1 h / 20 °C

2.1: potassium carbonate; tri tert-butylphosphoniumtetrafluoroborate / palladium diacetate / toluene / 20 h / 110 °C

3.1: trichlorophosphate / N,N-dimethyl-formamide; toluene / Reflux

4.1: tetrabutyl ammonium fluoride / palladium bis[bis(diphenylphosphino)ferrocene] dichloride / tetrahydrofuran / 3 h / Inert atmosphere; Heating

5.1: AD-mix α / water; tert-butyl alcohol / 12 h / 0 - 20 °C

With AD-mix α; tetrabutyl ammonium fluoride; dihydrogen peroxide; potassium carbonate; tri tert-butylphosphoniumtetrafluoroborate; trichlorophosphate; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; palladium diacetate; methyltrioxorhenium(VII); In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;

Reference yield:

1-Bromo-4-fluorobenzene (460-00-4) → C20H15FN2O3 (1367127-58-9)

Guidance literature:

Multi-step reaction with 5 steps

1: caesium carbonate; dimethylaminoacetic acid / copper(l) iodide / 1,4-dioxane / 20 h / 90 °C

2: potassium carbonate; tri tert-butylphosphoniumtetrafluoroborate / palladium diacetate / toluene / 20 h / 110 °C

3: trichlorophosphate / N,N-dimethyl-formamide; toluene / Reflux

4: tetrabutyl ammonium fluoride / palladium bis[bis(diphenylphosphino)ferrocene] dichloride / tetrahydrofuran / 3 h / Inert atmosphere; Heating

5: AD-mix α / water; tert-butyl alcohol / 12 h / 0 - 20 °C

With dimethylaminoacetic acid; AD-mix α; tetrabutyl ammonium fluoride; potassium carbonate; caesium carbonate; tri tert-butylphosphoniumtetrafluoroborate; trichlorophosphate; copper(l) iodide; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;

upstream raw materials:

2-Cyanopyridine

1-Bromo-4-fluorobenzene

4-Fluorophenol

1-bromo-4-(4-fluorophenoxy) benzene

Downstream raw materials:

C₂₀H₁₇FN₂O₄