N-<4-<<3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl>methylamino>benzoyl>-L-glutamic acid

Base Information

Chemical Name:N-<4-<<3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl>methylamino>benzoyl>-L-glutamic acid
CAS No.:118252-45-2
Molecular Formula:C₂₀H₂₆N₆O₆
Molecular Weight:446.463
Hs Code.:

Synonyms:N-<4-<<3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl>methylamino>benzoyl>-L-glutamic acid

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Chemical Property of N-<4-<<3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl>methylamino>benzoyl>-L-glutamic acid

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Technology Process of N-<4-<<3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl>methylamino>benzoyl>-L-glutamic acid

There total 7 articles about N-<4-<<3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl>methylamino>benzoyl>-L-glutamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 123541-76-4
(S)-2-(4-{[3-(2,4-Bis-acetylamino-6-oxo-1,6-dihydro-pyrimidin-5-yl)-propyl]-methyl-amino}-benzoylamino)-pentanedioic acid dimethyl ester

: 118252-45-2
N-<4-<<3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl>methylamino>benzoyl>-L-glutamic acid

Guidance literature:: With sodium hydroxide; In ethanol; at 70 ℃; for 20h;
DOI:10.1021/jm00164a014

Reference yield:

: 118252-49-6
3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propionaldehyde diethyl acetal

: 118252-45-2
N-<4-<<3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl>methylamino>benzoyl>-L-glutamic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 82 percent / pyridine / 1.) 90 deg C, 6 h, 2.) room temp., overnight

2: 76 percent / H₂O / 4 h / 100 °C

3: AcOH, 3A sieves / methanol / 3 h

4: NaBH₃CN, AcOH / methanol / 16 h

5: acetonitrile; dimethylformamide; H₂O

6: NaBH₃CN, AcOH / acetonitrile; dimethylformamide; H₂O / 18 h

7: 33 percent / 1 N NaOH / ethanol / 20 h / 70 °C

With pyridine; sodium hydroxide; 3 A molecular sieve; water; sodium cyanoborohydride; acetic acid; In methanol; ethanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00164a014

Reference yield:

: 118252-50-9
3-<2-(acetylamino)-4-(diacetylamino)-1,6-dihydro-6-oxo-5-pyrimidinyl>propionaldehyde diethyl acetal

: 118252-45-2
N-<4-<<3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl>methylamino>benzoyl>-L-glutamic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 76 percent / H₂O / 4 h / 100 °C

2: AcOH, 3A sieves / methanol / 3 h

3: NaBH₃CN, AcOH / methanol / 16 h

4: acetonitrile; dimethylformamide; H₂O

5: NaBH₃CN, AcOH / acetonitrile; dimethylformamide; H₂O / 18 h

6: 33 percent / 1 N NaOH / ethanol / 20 h / 70 °C

With sodium hydroxide; 3 A molecular sieve; water; sodium cyanoborohydride; acetic acid; In methanol; ethanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00164a014