1,7-bis-O-[2,3:4,6-di-O-isopropylidene-α-D-mannopyranosyl]-4-(p-4-tert-butylphenyloxymethyl)-hep-2,5-diyn-1,4,7-triol

Base Information

Chemical Name:1,7-bis-O-[2,3:4,6-di-O-isopropylidene-α-D-mannopyranosyl]-4-(p-4-tert-butylphenyloxymethyl)-hep-2,5-diyn-1,4,7-triol
CAS No.:854261-93-1
Molecular Formula:C₄₂H₅₈O₁₄
Molecular Weight:786.914
Hs Code.:

Synonyms:1,7-bis-O-[2,3:4,6-di-O-isopropylidene-α-D-mannopyranosyl]-4-(p-4-tert-butylphenyloxymethyl)-hep-2,5-diyn-1,4,7-triol

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Chemical Property of 1,7-bis-O-[2,3:4,6-di-O-isopropylidene-α-D-mannopyranosyl]-4-(p-4-tert-butylphenyloxymethyl)-hep-2,5-diyn-1,4,7-triol

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Technology Process of 1,7-bis-O-[2,3:4,6-di-O-isopropylidene-α-D-mannopyranosyl]-4-(p-4-tert-butylphenyloxymethyl)-hep-2,5-diyn-1,4,7-triol

There total 4 articles about 1,7-bis-O-[2,3:4,6-di-O-isopropylidene-α-D-mannopyranosyl]-4-(p-4-tert-butylphenyloxymethyl)-hep-2,5-diyn-1,4,7-triol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 854261-90-8
2-propynyl 2,3:4,6-di-O-isopropylidene-α-D-mannopyranoside

: 3344-19-2
4-tert-butyl-phenoxyacetic acid ethyl ester

: 854261-93-1
1,7-bis-O-[2,3:4,6-di-O-isopropylidene-α-D-mannopyranosyl]-4-(p-4-tert-butylphenyloxymethyl)-hep-2,5-diyn-1,4,7-triol

Guidance literature:: 2-propynyl 2,3:4,6-di-O-isopropylidene-α-D-mannopyranoside; With n-butyllithium; In tetrahydrofuran; hexane; at 0 ℃; for 1h;

4-tert-butyl-phenoxyacetic acid ethyl ester; In tetrahydrofuran; hexane; at 20 ℃; for 24h;
DOI:10.1055/s-2005-861828

Reference yield:

: 98-54-4
para-tert-butylphenol

: 854261-93-1
1,7-bis-O-[2,3:4,6-di-O-isopropylidene-α-D-mannopyranosyl]-4-(p-4-tert-butylphenyloxymethyl)-hep-2,5-diyn-1,4,7-triol

Guidance literature:: Multi-step reaction with 2 steps

1.1: 87.3 percent / K₂CO₃ / acetonitrile / 18 h / 20 °C

2.1: BuLi / tetrahydrofuran; hexane / 1 h / 0 °C

2.2: 95 percent / tetrahydrofuran; hexane / 24 h / 20 °C

With n-butyllithium; potassium carbonate; In tetrahydrofuran; hexane; acetonitrile;
DOI:10.1055/s-2005-861828

Reference yield:

: 83476-52-2
propargyl 2,3,4,6-tetra-O-acetyl-α-D-mannopyranoside

: 854261-93-1
1,7-bis-O-[2,3:4,6-di-O-isopropylidene-α-D-mannopyranosyl]-4-(p-4-tert-butylphenyloxymethyl)-hep-2,5-diyn-1,4,7-triol

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaOMe / methanol

2.1: 73 percent / camphor-10-sulfonic acid / acetone / 24 h / 20 °C

3.1: BuLi / tetrahydrofuran; hexane / 1 h / 0 °C

3.2: 95 percent / tetrahydrofuran; hexane / 24 h / 20 °C

With n-butyllithium; camphor-10-sulfonic acid; sodium methylate; In tetrahydrofuran; methanol; hexane; acetone; 1.1: Zemplen O-deacetylation;
DOI:10.1055/s-2005-861828