N-[7-benzyl-4-methyl-5-(phenylethynyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-N-(2,2-dimethylpropanoyl)-2,2-dimethylpropanamide

Base Information

Chemical Name:N-[7-benzyl-4-methyl-5-(phenylethynyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-N-(2,2-dimethylpropanoyl)-2,2-dimethylpropanamide
CAS No.:945910-52-1
Molecular Formula:C₃₂H₃₄N₄O₂
Molecular Weight:506.648
Hs Code.:

Synonyms:N-[7-benzyl-4-methyl-5-(phenylethynyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-N-(2,2-dimethylpropanoyl)-2,2-dimethylpropanamide

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Chemical Property of N-[7-benzyl-4-methyl-5-(phenylethynyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-N-(2,2-dimethylpropanoyl)-2,2-dimethylpropanamide

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Technology Process of N-[7-benzyl-4-methyl-5-(phenylethynyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-N-(2,2-dimethylpropanoyl)-2,2-dimethylpropanamide

There total 1 articles about N-[7-benzyl-4-methyl-5-(phenylethynyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-N-(2,2-dimethylpropanoyl)-2,2-dimethylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 536-74-3
phenylacetylene

: 306315-01-5
2,2-dipivaloylamino-4-methyl-5-iodo-7-(N-benzyl)pyrrolo[2,3-d]pyrimidine

: 945910-52-1
N-[7-benzyl-4-methyl-5-(phenylethynyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-N-(2,2-dimethylpropanoyl)-2,2-dimethylpropanamide

Guidance literature:: With triethylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dichloro-ethane; at 20 ℃; for 24h;
DOI:10.1021/jm070194u

Reference yield: 100.0%

: 945910-52-1
N-[7-benzyl-4-methyl-5-(phenylethynyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-N-(2,2-dimethylpropanoyl)-2,2-dimethylpropanamide

: 945910-53-2
N-[7-benzyl-4-methyl-5-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-N-(2,2-dimethylpropanoyl)-2,2-dimethylpropanamide

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; dichloromethane; for 3.5h; under 2585.81 Torr;
DOI:10.1021/jm070194u

Reference yield:

: 945910-52-1
N-[7-benzyl-4-methyl-5-(phenylethynyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-N-(2,2-dimethylpropanoyl)-2,2-dimethylpropanamide

: 904705-26-6
C₂₂H₂₂N₄

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / H₂ / Pd/C / CH₂Cl₂; methanol / 3.5 h / 2585.81 Torr

2: 79 percent / aq. NaOH / methanol / 24 h / 80 °C

With sodium hydroxide; hydrogen; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/jm070194u