5-[2,3-dichloro-4-(2-methylene-1-oxobutyl)phenoxymethyl]-3-methyl-1,2,4-oxadiazole

Base Information

Chemical Name:5-[2,3-dichloro-4-(2-methylene-1-oxobutyl)phenoxymethyl]-3-methyl-1,2,4-oxadiazole
CAS No.:1006585-48-3
Molecular Formula:C₁₅H₁₄Cl₂N₂O₃
Molecular Weight:341.194
Hs Code.:

Synonyms:5-[2,3-dichloro-4-(2-methylene-1-oxobutyl)phenoxymethyl]-3-methyl-1,2,4-oxadiazole

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Chemical Property of 5-[2,3-dichloro-4-(2-methylene-1-oxobutyl)phenoxymethyl]-3-methyl-1,2,4-oxadiazole

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Technology Process of 5-[2,3-dichloro-4-(2-methylene-1-oxobutyl)phenoxymethyl]-3-methyl-1,2,4-oxadiazole

There total 3 articles about 5-[2,3-dichloro-4-(2-methylene-1-oxobutyl)phenoxymethyl]-3-methyl-1,2,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 118493-85-9,117771-39-8,1141922-26-0,1429624-21-4
acetamide oxime

: 113239-57-9
<2,3-dichloro-4-(2-methylenebutyryl)phenoxy>acetyl chloride

: 1006585-48-3
5-[2,3-dichloro-4-(2-methylene-1-oxobutyl)phenoxymethyl]-3-methyl-1,2,4-oxadiazole

Guidance literature:: With pyridine; In toluene; at 100 ℃; for 1h;
DOI:10.1021/jm9011565

Reference yield:

: 2350-46-1
2',3'-dichloro-4'-hydroxybutyrophenone

: 1006585-48-3
5-[2,3-dichloro-4-(2-methylene-1-oxobutyl)phenoxymethyl]-3-methyl-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate; potassium iodide / acetone / 0.5 h

1.2: 4 h / 60 °C

1.3: 2 h / 20 °C

2.1: potassium carbonate / ethanol; water / 10 h / 90 °C

3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane; N,N-dimethyl-formamide / 0.5 h / 20 °C

4.1: potassium carbonate / acetone / 2 h / 20 °C

4.2: 9 h / 60 °C / Cooling with ice

With oxalyl dichloride; potassium carbonate; N,N-dimethyl-formamide; potassium iodide; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: 1217-67-0
<2,3-dichloro-4-(1-oxobutyl)phenyloxy>acetic acid

: 1006585-48-3
5-[2,3-dichloro-4-(2-methylene-1-oxobutyl)phenoxymethyl]-3-methyl-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / ethanol; water / 10 h / 90 °C

2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane; N,N-dimethyl-formamide / 0.5 h / 20 °C

3.1: potassium carbonate / acetone / 2 h / 20 °C

3.2: 9 h / 60 °C / Cooling with ice

With oxalyl dichloride; potassium carbonate; N,N-dimethyl-formamide; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;