2-amino-4-(2-(trifluoromethyl)phenyl)thiazolo[4,5-d]pyridazin-7(6H)-one

Base Information

• Chemical Name: 2-amino-4-(2-(trifluoromethyl)phenyl)thiazolo[4,5-d]pyridazin-7(6H)-one
• CAS No.: 1188499-22-0
• Molecular Formula: C₁₂H₇F₃N₄OS
• Molecular Weight: 312.275
• Mol file: 1188499-22-0.mol

Synonyms:2-amino-4-(2-(trifluoromethyl)phenyl)thiazolo[4,5-d]pyridazin-7(6H)-one

Chemical Property of 2-amino-4-(2-(trifluoromethyl)phenyl)thiazolo[4,5-d]pyridazin-7(6H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-amino-4-(2-(trifluoromethyl)phenyl)thiazolo[4,5-d]pyridazin-7(6H)-one

There total 2 articles about 2-amino-4-(2-(trifluoromethyl)phenyl)thiazolo[4,5-d]pyridazin-7(6H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

N-(7-oxo-4-(2-(trifluoromethyl)phenyl)-6,7-dihydrothiazolo[4,5-d]pyridazin-2-yl)acetamide (1188499-19-5) → 2-amino-4-(2-(trifluoromethyl)phenyl)thiazolo[4,5-d]pyridazin-7(6H)-one (1188499-22-0)

Guidance literature:

With hydrazine hydrate; at 70 - 75 ℃; for 1h;

DOI:10.1016/j.tetlet.2009.07.105

Reference yield: 45.0%

2-acetamido-4-(2-(trifluoromethyl)benzoyl)thiazole-5-carboxylic acid (1188499-16-2) → 2-amino-4-(2-(trifluoromethyl)phenyl)thiazolo[4,5-d]pyridazin-7(6H)-one (1188499-22-0) + N-(7-oxo-4-(2-(trifluoromethyl)phenyl)-6,7-dihydrothiazolo[4,5-d]pyridazin-2-yl)acetamide (1188499-19-5) + C14H11F3N4O3S (1188499-33-3)

Guidance literature:

With hydrazine hydrate; In ethanol; at 80 ℃; for 4h;

DOI:10.1016/j.tetlet.2009.07.105

Reference yield: 48.0%

2-amino-4-(2-(trifluoromethyl)phenyl)thiazolo[4,5-d]pyridazin-7(6H)-one (1188499-22-0) + benzoic acid (65-85-0,8013-63-6) → C19H11F3N4O2S (1188499-25-3)

Guidance literature:

With hydrogenchloride; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 26 ℃; for 15h; Under N₂ atmosphere;

DOI:10.1016/j.tetlet.2009.07.105

upstream raw materials:

2-acetamido-4-(2-(trifluoromethyl)benzoyl)thiazole-5-carboxylic acid

N-(7-oxo-4-(2-(trifluoromethyl)phenyl)-6,7-dihydrothiazolo[4,5-d]pyridazin-2-yl)acetamide

Downstream raw materials:

C₂₄H₂₀F₃N₅O₄S₂

2-(1-benzenesulfonylpiperidin-3-yl)-N-[7-oxo-4-(2-trifluoromethylphenyl)-6,7-dihydrothiazolo[4,5-d]pyridazin-2-yl]-acetamide

2,4-dichloro-N-[7-oxo-4-(2-trifluoromethylphenyl)-6,7-dihydrothiazolo[4,5-d]pyridazin-2-yl]-benzamide

C₁₉H₁₀F₄N₄O₂S