tert-butyl [(1RS)-3-methyl-1-(4-oxo-3,4-dihydroquinazolin-2-yl)butyl]carbamate

Base Information

Chemical Name:tert-butyl [(1RS)-3-methyl-1-(4-oxo-3,4-dihydroquinazolin-2-yl)butyl]carbamate
CAS No.:1206450-63-6
Molecular Formula:C₁₈H₂₅N₃O₃
Molecular Weight:331.415
Hs Code.:

Synonyms:tert-butyl [(1RS)-3-methyl-1-(4-oxo-3,4-dihydroquinazolin-2-yl)butyl]carbamate

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Chemical Property of tert-butyl [(1RS)-3-methyl-1-(4-oxo-3,4-dihydroquinazolin-2-yl)butyl]carbamate

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Technology Process of tert-butyl [(1RS)-3-methyl-1-(4-oxo-3,4-dihydroquinazolin-2-yl)butyl]carbamate

There total 1 articles about tert-butyl [(1RS)-3-methyl-1-(4-oxo-3,4-dihydroquinazolin-2-yl)butyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 13139-15-6,53296-34-7
Boc-DL-Leu-OH

: 28144-70-9,88-68-6
anthranilic acid amide

: 1206450-63-6
tert-butyl [(1RS)-3-methyl-1-(4-oxo-3,4-dihydroquinazolin-2-yl)butyl]carbamate

Guidance literature:: Boc-DL-Leu-OH; With 4-methyl-morpholine; chloromethyl isobutyl carbonate; In tetrahydrofuran; at -15 ℃; for 1h; Inert atmosphere;

anthranilic acid amide; In tetrahydrofuran; at 20 ℃; Inert atmosphere; Reflux;

With sodium methylate; In tetrahydrofuran; methanol; for 3h; Inert atmosphere; Reflux;
DOI:10.1055/s-0034-1378675

Reference yield:

: 1206450-63-6
tert-butyl [(1RS)-3-methyl-1-(4-oxo-3,4-dihydroquinazolin-2-yl)butyl]carbamate

: (1R,3R)-1-[(benzyloxy)methyl]-3-isobutyl-2,3-dihydroimidazo[5,1-b]quinazolin-9(1H)-one

: (1R,3S)-1-[(benzyloxy)methyl]-3-isobutyl-2,3-dihydroimidazo[5,1-b]quinazolin-9(1H)-one

: (1S,3R)-1-[(benzyloxy)methyl]-3-isobutyl-2,3-dihydroimidazo[5,1-b]quinazolin-9(1H)-one

: (1S,3S)-1-[(benzyloxy)methyl]-3-isobutyl-2,3-dihydroimidazo[5,1-b]quinazolin-9(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / dichloromethane / 12 h / 20 °C

2: methanol / 12 h / Reflux

With hydrogenchloride; In methanol; dichloromethane;
DOI:10.1055/s-0034-1378675

Reference yield:

: 1206450-63-6
tert-butyl [(1RS)-3-methyl-1-(4-oxo-3,4-dihydroquinazolin-2-yl)butyl]carbamate

: (1R,3R)-1-benzyl-3-isobutyl-2,3-dihydroimidazo[5,1-b]quinazolin-9(1H)-one

: (1R,3S)-1-benzyl-3-isobutyl-2,3-dihydroimidazo[5,1-b]quinazolin-9(1H)-one

: (1S,3R)-1-benzyl-3-isobutyl-2,3-dihydroimidazo[5,1-b]quinazolin-9(1H)-one

: (1S,3S)-1-benzyl-3-isobutyl-2,3-dihydroimidazo[5,1-b]quinazolin-9(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / dichloromethane / 12 h / 20 °C

2: methanol / 12 h / Reflux

With hydrogenchloride; In methanol; dichloromethane;
DOI:10.1055/s-0034-1378675