4-(1-(2-ethyl-6-(trifluoromethyl)benzyl)-4-fluoro-1H-indazol-3-yl)-5-fluoro-2-hydroxybenzoic acid

Base Information

Chemical Name:4-(1-(2-ethyl-6-(trifluoromethyl)benzyl)-4-fluoro-1H-indazol-3-yl)-5-fluoro-2-hydroxybenzoic acid
CAS No.:1562194-13-1
Molecular Formula:C₂₄H₁₇F₅N₂O₃
Molecular Weight:476.403
Hs Code.:

Synonyms:4-(1-(2-ethyl-6-(trifluoromethyl)benzyl)-4-fluoro-1H-indazol-3-yl)-5-fluoro-2-hydroxybenzoic acid

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Chemical Property of 4-(1-(2-ethyl-6-(trifluoromethyl)benzyl)-4-fluoro-1H-indazol-3-yl)-5-fluoro-2-hydroxybenzoic acid

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Technology Process of 4-(1-(2-ethyl-6-(trifluoromethyl)benzyl)-4-fluoro-1H-indazol-3-yl)-5-fluoro-2-hydroxybenzoic acid

There total 10 articles about 4-(1-(2-ethyl-6-(trifluoromethyl)benzyl)-4-fluoro-1H-indazol-3-yl)-5-fluoro-2-hydroxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.8%

: 1562195-42-9
methyl 4-(1-(2-ethyl-6-(trifluoromethyl)benzyl)-4-fluoro-1H-indazol-3-yl)-5-fluoro-2-methoxybenzoate

: 1562194-13-1
4-(1-(2-ethyl-6-(trifluoromethyl)benzyl)-4-fluoro-1H-indazol-3-yl)-5-fluoro-2-hydroxybenzoic acid

Guidance literature:: With boron tribromide; In dichloromethane; at -30 - 10 ℃;

Reference yield:

: 341-23-1
4-fluoro-1H-indazole

: 1562194-13-1
4-(1-(2-ethyl-6-(trifluoromethyl)benzyl)-4-fluoro-1H-indazol-3-yl)-5-fluoro-2-hydroxybenzoic acid

Guidance literature:: Multi-step reaction with 8 steps

1: iodine; potassium hydroxide / N,N-dimethyl-formamide / 0 - 20 °C

2: toluene-4-sulfonic acid / tetrahydrofuran / 6 h / Reflux

3: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / toluene; ethanol / 6 h / 120 °C / Inert atmosphere

4: hydrogenchloride; methanol / 14 h / Reflux

5: caesium carbonate / N,N-dimethyl-formamide / 3 h / 10 °C

6: potassium phosphate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; 1,4-dioxane / 16 h / 100 °C

7: palladium on activated charcoal; hydrogen / ethyl acetate / 3 h / 10 °C

8: boron tribromide / dichloromethane / -30 - 10 °C

With hydrogenchloride; methanol; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium on activated charcoal; hydrogen; iodine; boron tribromide; sodium carbonate; caesium carbonate; toluene-4-sulfonic acid; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene; 3: |Suzuki Coupling;

Reference yield:

: 1562195-39-4
methyl 5-fluoro-4-(4-fluoro-1-(2-(trifluoromethyl)-6-vinylbenzyl)-1H-indazol-3-yl)-2-methoxybenzoate

: 1562194-13-1
4-(1-(2-ethyl-6-(trifluoromethyl)benzyl)-4-fluoro-1H-indazol-3-yl)-5-fluoro-2-hydroxybenzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: palladium on activated charcoal; hydrogen / ethyl acetate / 3 h / 10 °C

2: boron tribromide / dichloromethane / -30 - 10 °C

With palladium on activated charcoal; hydrogen; boron tribromide; In dichloromethane; ethyl acetate;