2-{5-[3-(4-tert-butyl-phenoxy)-phenyl]-2-oxo-2,3-dihydro-imidazol-1-yl}-hexanoic acid methyl ester

Base Information

• Chemical Name: 2-{5-[3-(4-tert-butyl-phenoxy)-phenyl]-2-oxo-2,3-dihydro-imidazol-1-yl}-hexanoic acid methyl ester
• CAS No.: 556817-21-1
• Molecular Formula: C₂₆H₃₂N₂O₄
• Molecular Weight: 436.551

Synonyms:2-{5-[3-(4-tert-butyl-phenoxy)-phenyl]-2-oxo-2,3-dihydro-imidazol-1-yl}-hexanoic acid methyl ester

Chemical Property of 2-{5-[3-(4-tert-butyl-phenoxy)-phenyl]-2-oxo-2,3-dihydro-imidazol-1-yl}-hexanoic acid methyl ester

Chemical Property:

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Technology Process of 2-{5-[3-(4-tert-butyl-phenoxy)-phenyl]-2-oxo-2,3-dihydro-imidazol-1-yl}-hexanoic acid methyl ester

There total 1 articles about 2-{5-[3-(4-tert-butyl-phenoxy)-phenyl]-2-oxo-2,3-dihydro-imidazol-1-yl}-hexanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

2-(3-{2-[3-(4-tert-butyl-phenoxy)-phenyl]-2-oxo-ethyl}-ureido)-hexanoic acid methyl ester (556817-20-0) → 2-{5-[3-(4-tert-butyl-phenoxy)-phenyl]-2-oxo-2,3-dihydro-imidazol-1-yl}-hexanoic acid methyl ester (556817-21-1) + 5-butyl-3-{2-[3-(4-tert-butyl-phenoxy)-phenyl]-2-oxo-ethyl}-imidazolidine-2,4-dione

Guidance literature:

With sulfuric acid; In methanol; Heating;

DOI:10.1016/S0960-894X(02)01076-4

Reference yield: 84.0%

bromoacetic acid tert-butyl ester (5292-43-3) + 2-{5-[3-(4-tert-butyl-phenoxy)-phenyl]-2-oxo-2,3-dihydro-imidazol-1-yl}-hexanoic acid methyl ester (556817-21-1) → 2-{3-tert-butoxycarbonylmethyl-5-[3-(4-tert-butyl-phenoxy)-phenyl]-2-oxo-2,3-dihydro-imidazol-1-yl}-hexanoic acid methyl ester (556817-23-3)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃;

DOI:10.1016/S0960-894X(02)01076-4

Reference yield:

2-{5-[3-(4-tert-butyl-phenoxy)-phenyl]-2-oxo-2,3-dihydro-imidazol-1-yl}-hexanoic acid methyl ester (556817-21-1) → 2-{5-[3-(4-tert-butyl-phenoxy)-phenyl]-2-oxo-2,3-dihydro-imidazol-1-yl}-hexanoic acid

Guidance literature:

With sodium hydroxide; In methanol;

DOI:10.1016/S0960-894X(02)01076-4

upstream raw materials:

2-(3-{2-[3-(4-tert-butyl-phenoxy)-phenyl]-2-oxo-ethyl}-ureido)-hexanoic acid methyl ester

Downstream raw materials:

2-{3-tert-butoxycarbonylmethyl-5-[3-(4-tert-butyl-phenoxy)-phenyl]-2-oxo-2,3-dihydro-imidazol-1-yl}-hexanoic acid methyl ester

2-{5-[3-(4-tert-butyl-phenoxy)-phenyl]-3-carboxymethyl-2-oxo-2,3-dihydro-imidazol-1-yl}-hexanoic acid methyl ester

2-(5-[3-(4-tert-butyl-phenoxy)-phenyl]-3-{[2-(2-chloro-phenyl)-ethylcarbamoyl]-methyl}-2-oxo-2,3-dihydro-imidazol-1-yl)-hexanoic acid methyl ester

2-{5-[3-(4-tert-butyl-phenoxy)-phenyl]-3-[(3,4-dichloro-benzylcarbamoyl)-methyl]-2-oxo-2,3-dihydro-imidazol-1-yl}-hexanoic acid methyl ester

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