allyl-(8-chloro-6-phenyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-1-ylmethyl)-amine

Base Information

• Chemical Name: allyl-(8-chloro-6-phenyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-1-ylmethyl)-amine
• CAS No.: 61532-91-0
• Molecular Formula: C₂₀H₁₈ClN₅
• Molecular Weight: 363.849

Synonyms:allyl-(8-chloro-6-phenyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-1-ylmethyl)-amine

Chemical Property of allyl-(8-chloro-6-phenyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-1-ylmethyl)-amine

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Technology Process of allyl-(8-chloro-6-phenyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-1-ylmethyl)-amine

There total 4 articles about allyl-(8-chloro-6-phenyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-1-ylmethyl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.1%

8-chloro-1-(chloromethyl)-6-phenyl-4H-s-triazolo<4,3-a><1,4>benzodiazepine (39479-72-6) + 1-amino-2-propene (107-11-9,30551-89-4) → allyl-(8-chloro-6-phenyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-1-ylmethyl)-amine (61532-91-0)

Guidance literature:

With potassium iodide; In tetrahydrofuran; at 25 ℃; for 18h;

DOI:10.1021/jm00178a009

Reference yield:

Chloro-acetic acid N'-(7-chloro-5-phenyl-3H-benzo[e][1,4]diazepin-2-yl)-hydrazide → allyl-(8-chloro-6-phenyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-1-ylmethyl)-amine (61532-91-0)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid / 0.33 h / Heating

2: 34.1 percent / KI / tetrahydrofuran / 18 h / 25 °C

With potassium iodide; In tetrahydrofuran; acetic acid;

DOI:10.1021/jm00178a009

Reference yield:

7-chloro-2-hydrazino-5-phenyl-3H-1,4-benzodiazepine (18091-89-9,112393-62-1) → allyl-(8-chloro-6-phenyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-1-ylmethyl)-amine (61532-91-0)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran / 1.58 h / 0 - 20 °C

2: acetic acid / 0.33 h / Heating

3: 34.1 percent / KI / tetrahydrofuran / 18 h / 25 °C

With potassium iodide; In tetrahydrofuran; acetic acid;

DOI:10.1021/jm00178a009

upstream raw materials:

8-chloro-1-(chloromethyl)-6-phenyl-4H-s-triazolo<4,3-a><1,4>benzodiazepine

1-amino-2-propene

7-chloro-2-hydrazino-5-phenyl-3H-1,4-benzodiazepine

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