(R)-methyl 3-(benzyloxy)-2-((benzyloxycarbonyl)(2,2-dimethoxyethyl)amino)-propanoate

Base Information

Chemical Name:(R)-methyl 3-(benzyloxy)-2-((benzyloxycarbonyl)(2,2-dimethoxyethyl)amino)-propanoate
CAS No.:1401109-59-8
Molecular Formula:C₂₃H₂₉NO₇
Molecular Weight:431.486
Hs Code.:

Synonyms:(R)-methyl 3-(benzyloxy)-2-((benzyloxycarbonyl)(2,2-dimethoxyethyl)amino)-propanoate

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Chemical Property of (R)-methyl 3-(benzyloxy)-2-((benzyloxycarbonyl)(2,2-dimethoxyethyl)amino)-propanoate

Chemical Property:

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Technology Process of (R)-methyl 3-(benzyloxy)-2-((benzyloxycarbonyl)(2,2-dimethoxyethyl)amino)-propanoate

There total 1 articles about (R)-methyl 3-(benzyloxy)-2-((benzyloxycarbonyl)(2,2-dimethoxyethyl)amino)-propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1401109-68-9
C₁₅H₂₃NO₅

: 501-53-1,94274-21-2
benzyl chloroformate

: 1401109-59-8
(R)-methyl 3-(benzyloxy)-2-((benzyloxycarbonyl)(2,2-dimethoxyethyl)amino)-propanoate

Guidance literature:: With potassium hydrogencarbonate; In 1,4-dioxane; water; at 0 - 20 ℃; for 2.25h; Inert atmosphere;
DOI:10.1016/j.tet.2012.08.048

Reference yield: 82.0%

: 1401109-59-8
(R)-methyl 3-(benzyloxy)-2-((benzyloxycarbonyl)(2,2-dimethoxyethyl)amino)-propanoate

: 1401109-60-1
(S)-benzyl (1-(benzyloxy)-3-hydroxypropan-2-yl)(2,2-dimethoxyethyl)carbamate

Guidance literature:: With lithium triethylborohydride; In tetrahydrofuran; at 0 ℃; for 1.5h; Inert atmosphere;
DOI:10.1016/j.tet.2012.08.048

Reference yield:

: 1401109-59-8
(R)-methyl 3-(benzyloxy)-2-((benzyloxycarbonyl)(2,2-dimethoxyethyl)amino)-propanoate

: 1401109-64-5
C₂₂H₂₅NO₅

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium triethylborohydride / tetrahydrofuran / 1.5 h / 0 °C / Inert atmosphere

2.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide; dichloromethane / 24 h / 50 °C / Inert atmosphere

3.1: tetrahydrofuran / 3 h / -50 - 20 °C / Inert atmosphere

3.2: Inert atmosphere

4.1: formic acid / 16 h / 20 °C / Inert atmosphere

5.1: iron pentacarbonyl / tetrahydrofuran / Irradiation; Heating; Inert atmosphere

With formic acid; iron pentacarbonyl; lithium triethylborohydride; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/j.tet.2012.08.048