2,2-Dimethyl-propionic acid 1-(4-chloro-benzoylamino)-2-(4-chloro-phenyl)-2-oxo-ethyl ester

Base Information

• Chemical Name: 2,2-Dimethyl-propionic acid 1-(4-chloro-benzoylamino)-2-(4-chloro-phenyl)-2-oxo-ethyl ester
• CAS No.: 78010-64-7
• Molecular Formula: C₂₀H₁₉Cl₂NO₄
• Molecular Weight: 408.281

Synonyms:2,2-Dimethyl-propionic acid 1-(4-chloro-benzoylamino)-2-(4-chloro-phenyl)-2-oxo-ethyl ester

Chemical Property of 2,2-Dimethyl-propionic acid 1-(4-chloro-benzoylamino)-2-(4-chloro-phenyl)-2-oxo-ethyl ester

Chemical Property:

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Technology Process of 2,2-Dimethyl-propionic acid 1-(4-chloro-benzoylamino)-2-(4-chloro-phenyl)-2-oxo-ethyl ester

There total 2 articles about 2,2-Dimethyl-propionic acid 1-(4-chloro-benzoylamino)-2-(4-chloro-phenyl)-2-oxo-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

4-Chloro-N-[1-chloro-2-(4-chloro-phenyl)-2-oxo-ethyl]-benzamide (78010-53-4) + Trimethylacetic acid (75-98-9) → 2,2-Dimethyl-propionic acid 1-(4-chloro-benzoylamino)-2-(4-chloro-phenyl)-2-oxo-ethyl ester (78010-64-7)

Guidance literature:

With triethylamine; In tetrahydrofuran; for 1h;

DOI:10.1002/ardp.19813140305

Reference yield:

4-Chloro-N-[2-(4-chloro-phenyl)-1-hydroxy-2-oxo-ethyl]-benzamide (78010-49-8) → 2,2-Dimethyl-propionic acid 1-(4-chloro-benzoylamino)-2-(4-chloro-phenyl)-2-oxo-ethyl ester (78010-64-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / CHCl₃; tetrahydrofuran / 0.5 h / Heating

2: 83 percent / (C₂H₅)3N / tetrahydrofuran / 1 h

With triethylamine; In tetrahydrofuran; chloroform;

DOI:10.1002/ardp.19813140305

Reference yield: 76.0%

2,2-Dimethyl-propionic acid 1-(4-chloro-benzoylamino)-2-(4-chloro-phenyl)-2-oxo-ethyl ester (78010-64-7) + phenylmethanethiol (100-53-8) → N-[1-Benzylsulfanyl-2-(4-chloro-phenyl)-2-oxo-ethyl]-4-chloro-benzamide (78010-72-7)

Guidance literature:

With triethylamine; In tetrahydrofuran; for 3h; Ambient temperature;

DOI:10.1002/ardp.19813140305

upstream raw materials:

4-Chloro-N-[1-chloro-2-(4-chloro-phenyl)-2-oxo-ethyl]-benzamide

Trimethylacetic acid

4-Chloro-N-[2-(4-chloro-phenyl)-1-hydroxy-2-oxo-ethyl]-benzamide

Downstream raw materials:

4-Chloro-N-[2-(4-chloro-phenyl)-1-methoxy-2-oxo-ethyl]-benzamide

N-[1-Benzylsulfanyl-2-(4-chloro-phenyl)-2-oxo-ethyl]-4-chloro-benzamide

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