3-methyl-2-[4-(trifluoromethyl)phenyl]-3H-imidazole-4-carboxylic acid

Base Information

• Chemical Name: 3-methyl-2-[4-(trifluoromethyl)phenyl]-3H-imidazole-4-carboxylic acid
• CAS No.: 1373150-44-7
• Molecular Formula: C₁₂H₉F₃N₂O₂
• Molecular Weight: 270.211
• Mol file: 1373150-44-7.mol

Synonyms:3-methyl-2-[4-(trifluoromethyl)phenyl]-3H-imidazole-4-carboxylic acid

Chemical Property of 3-methyl-2-[4-(trifluoromethyl)phenyl]-3H-imidazole-4-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 3-methyl-2-[4-(trifluoromethyl)phenyl]-3H-imidazole-4-carboxylic acid

There total 2 articles about 3-methyl-2-[4-(trifluoromethyl)phenyl]-3H-imidazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 1-methyl-2-[4-(trifluoromethyl)phenyl]-1H-imidazole-5-carboxylate (1202942-02-6) → 3-methyl-2-[4-(trifluoromethyl)phenyl]-3H-imidazole-4-carboxylic acid (1373150-44-7)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; at 80 ℃; for 1.5h;

Reference yield:

4-trifluoromethylphenylboronic acid (128796-39-4) + 2-bromo-3-methyl-3H-imidazole-4-carboxylic acid methyl ester (120781-02-4) → 3-methyl-2-[4-(trifluoromethyl)phenyl]-3H-imidazole-4-carboxylic acid (1373150-44-7)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; tetrahydrofuran / 0.5 h / 120 °C / Microwave irradiation

2: sodium hydroxide / tetrahydrofuran / 1.5 h / 80 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; sodium hydroxide; In tetrahydrofuran; water;

Reference yield:

5-methyl-6-[4-(morpholin-4-yl)cyclohex-1-en-1-yl]pyridin-3-amine (1373148-71-0) + 3-methyl-2-[4-(trifluoromethyl)phenyl]-3H-imidazole-4-carboxylic acid (1373150-44-7) → 3-methyl-N-{5-methyl-6-[4-(morpholin-4-yl)cyclohex-1-en-1-yl]pyridin-3-yl}-2-[4-(trifluoromethyl)phenyl]-3H-imidazole-4-carboxamide (1373143-62-4)

Guidance literature:

3-methyl-2-[4-(trifluoromethyl)phenyl]-3H-imidazole-4-carboxylic acid; With thionyl chloride; N,N-dimethyl-formamide; In toluene; at 80 ℃; for 1.33333h;

5-methyl-6-[4-(morpholin-4-yl)cyclohex-1-en-1-yl]pyridin-3-amine; With triethylamine; In dichloromethane; at 20 ℃; Cooling with ice;

upstream raw materials:

methyl 1-methyl-2-[4-(trifluoromethyl)phenyl]-1H-imidazole-5-carboxylate

4-trifluoromethylphenylboronic acid

2-bromo-3-methyl-3H-imidazole-4-carboxylic acid methyl ester

Downstream raw materials:

3-methyl-N-{5-methyl-6-[4-(morpholin-4-yl)cyclohex-1-en-1-yl]pyridin-3-yl}-2-[4-(trifluoromethyl)phenyl]-3H-imidazole-4-carboxamide