5-chloro-6-((6-fluoropyridin-2-yl)methoxy)-3-(5-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-2-methylphenyl)-2-methylpyrimidin-4(3H)-one

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Chemical Name:5-chloro-6-((6-fluoropyridin-2-yl)methoxy)-3-(5-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-2-methylphenyl)-2-methylpyrimidin-4(3H)-one
CAS No.:1442451-88-8
Molecular Formula:C₂₅H₂₃ClFN₅O₃
Molecular Weight:495.941
Hs Code.:

Synonyms:5-chloro-6-((6-fluoropyridin-2-yl)methoxy)-3-(5-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-2-methylphenyl)-2-methylpyrimidin-4(3H)-one

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Chemical Property of 5-chloro-6-((6-fluoropyridin-2-yl)methoxy)-3-(5-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-2-methylphenyl)-2-methylpyrimidin-4(3H)-one

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Technology Process of 5-chloro-6-((6-fluoropyridin-2-yl)methoxy)-3-(5-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-2-methylphenyl)-2-methylpyrimidin-4(3H)-one

There total 10 articles about 5-chloro-6-((6-fluoropyridin-2-yl)methoxy)-3-(5-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-2-methylphenyl)-2-methylpyrimidin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 1442452-46-1
5-chloro-6-(6-fluoro-pyridin-2-ylmethoxy)-2-methyl-3-(2-methyl-5-propynoyl-phenyl)-3H-pyrimidin-4-one

: 2-hydroxy-2-methylpropanimidamide hydrochloride

: 1442451-88-8
5-chloro-6-((6-fluoropyridin-2-yl)methoxy)-3-(5-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-2-methylphenyl)-2-methylpyrimidin-4(3H)-one

Guidance literature:: With potassium carbonate; In acetonitrile; at 75 ℃; for 18h;

Reference yield:

: 315180-16-6
6-(chloromethyl)-2-fluoropyridine

: 1442451-88-8
5-chloro-6-((6-fluoropyridin-2-yl)methoxy)-3-(5-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-2-methylphenyl)-2-methylpyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate; 18-crown-6 ether / N,N-dimethyl-formamide / 18 h / 45 °C

2.1: sodium hydroxide / tetrahydrofuran / 18 h / 20 °C

2.2: 1 h / 20 °C

2.3: 18 h

3.1: tetrahydrofuran / 0.5 h / Cooling with ice

4.1: potassium carbonate / acetonitrile / 18 h / 75 °C

With 18-crown-6 ether; potassium carbonate; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1442452-43-8
3-[5-chloro-4-(6-fluoro-pyridin-2-ylmethoxy)-2-methyl-6-oxo-6H-pyrimidin-1-yl]-4-methyl-benzoic acid methyl ester

: 1442451-88-8
5-chloro-6-((6-fluoropyridin-2-yl)methoxy)-3-(5-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-2-methylphenyl)-2-methylpyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / tetrahydrofuran / 18 h / 20 °C

1.2: 1 h / 20 °C

1.3: 18 h

2.1: tetrahydrofuran / 0.5 h / Cooling with ice

3.1: potassium carbonate / acetonitrile / 18 h / 75 °C

With potassium carbonate; sodium hydroxide; In tetrahydrofuran; acetonitrile;