4-(4-(2,6-dichlorophenylamino)-5-fluoropyrimidin-2-ylamino)benzoic acid hydrochloride

Base Information

Chemical Name:4-(4-(2,6-dichlorophenylamino)-5-fluoropyrimidin-2-ylamino)benzoic acid hydrochloride
CAS No.:1402141-36-9
Molecular Formula:C₁₇H₁₁Cl₂FN₄O₂*ClH
Molecular Weight:429.665
Hs Code.:

Synonyms:4-(4-(2,6-dichlorophenylamino)-5-fluoropyrimidin-2-ylamino)benzoic acid hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(4-(2,6-dichlorophenylamino)-5-fluoropyrimidin-2-ylamino)benzoic acid hydrochloride

Chemical Property:

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Technology Process of 4-(4-(2,6-dichlorophenylamino)-5-fluoropyrimidin-2-ylamino)benzoic acid hydrochloride

There total 2 articles about 4-(4-(2,6-dichlorophenylamino)-5-fluoropyrimidin-2-ylamino)benzoic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1402141-34-7
2-chloro-N-(2,6-dichlorophenyl)-5-fluoropyrimidin-4-amine

: 150-13-0,159246-81-8,8014-65-1
4-amino-benzoic acid

: 1402141-36-9
4-(4-(2,6-dichlorophenylamino)-5-fluoropyrimidin-2-ylamino)benzoic acid hydrochloride

Guidance literature:: In ethanol; at 100 ℃; for 18h;

Reference yield:

: 608-31-1
2,6-Dichloroaniline

: 1402141-36-9
4-(4-(2,6-dichlorophenylamino)-5-fluoropyrimidin-2-ylamino)benzoic acid hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere

1.2: 14 h / Inert atmosphere

2.1: ethanol / 18 h / 100 °C

With sodium hydride; In ethanol; N,N-dimethyl-formamide;