(αS)-methyl 4-[[4-(3,4-dichlorophenoxy)-1-piperidinyl]methyl]-α-((4-fluorophenyl)methyl)-1-piperidineacetate

Base Information

Chemical Name:(αS)-methyl 4-[[4-(3,4-dichlorophenoxy)-1-piperidinyl]methyl]-α-((4-fluorophenyl)methyl)-1-piperidineacetate
CAS No.:921204-93-5
Molecular Formula:C₂₈H₃₅Cl₂FN₂O₃
Molecular Weight:537.502
Hs Code.:

Synonyms:(αS)-methyl 4-[[4-(3,4-dichlorophenoxy)-1-piperidinyl]methyl]-α-((4-fluorophenyl)methyl)-1-piperidineacetate

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Chemical Property of (αS)-methyl 4-[[4-(3,4-dichlorophenoxy)-1-piperidinyl]methyl]-α-((4-fluorophenyl)methyl)-1-piperidineacetate

Chemical Property:

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Technology Process of (αS)-methyl 4-[[4-(3,4-dichlorophenoxy)-1-piperidinyl]methyl]-α-((4-fluorophenyl)methyl)-1-piperidineacetate

There total 4 articles about (αS)-methyl 4-[[4-(3,4-dichlorophenoxy)-1-piperidinyl]methyl]-α-((4-fluorophenyl)methyl)-1-piperidineacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 124980-98-9
(R)-methyl 3-(4-fluorophenyl)-2-hydroxypropanoate

: 676517-45-6
4-(3,4-dichloro-2-methylphenoxy)-1-(piperidin-4-ylmethyl)-piperidine

: 921204-93-5
(αS)-methyl 4-[[4-(3,4-dichlorophenoxy)-1-piperidinyl]methyl]-α-((4-fluorophenyl)methyl)-1-piperidineacetate

Guidance literature:: (R)-methyl 3-(4-fluorophenyl)-2-hydroxypropanoate; With 2,6-dimethylpyridine; trifluoromethylsulfonic anhydride; In dichloromethane; at 0 - 20 ℃; for 2.4h; Molecular sieve;

4-(3,4-dichloro-2-methylphenoxy)-1-(piperidin-4-ylmethyl)-piperidine; With triethylamine; In dichloromethane; at 0 ℃; for 1h; Product distribution / selectivity;

Reference yield:

: 3-(4-fluorophenyl)-2-(4-nitrobenzenesulfonyloxy)propionic acid methyl ester

: 4-[4-(3,4-dichloro-2-methylphenoxy)piperidin-1-ylmethyl]piperidine di-benzenesulfonate salt

: 921204-93-5
(αS)-methyl 4-[[4-(3,4-dichlorophenoxy)-1-piperidinyl]methyl]-α-((4-fluorophenyl)methyl)-1-piperidineacetate

Guidance literature:: 4-[4-(3,4-dichloro-2-methylphenoxy)piperidin-1-ylmethyl]piperidine di-benzenesulfonate salt; With sodium hydroxide; In tert-butyl methyl ether; water; at 25 - 30 ℃; for 0.333333h;

3-(4-fluorophenyl)-2-(4-nitrobenzenesulfonyloxy)propionic acid methyl ester; With potassium carbonate; In acetonitrile; at 60 - 65 ℃; for 16h; Product distribution / selectivity;