tert-butyl 4-(4-cyano-3-trifluoromethylphenylaminooxalyl)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(4-cyano-3-trifluoromethylphenylaminooxalyl)piperidine-1-carboxylate
CAS No.:1161783-85-2
Molecular Formula:C₂₀H₂₂F₃N₃O₄
Molecular Weight:425.408
Hs Code.:

Synonyms:tert-butyl 4-(4-cyano-3-trifluoromethylphenylaminooxalyl)piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-(4-cyano-3-trifluoromethylphenylaminooxalyl)piperidine-1-carboxylate

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Technology Process of tert-butyl 4-(4-cyano-3-trifluoromethylphenylaminooxalyl)piperidine-1-carboxylate

There total 1 articles about tert-butyl 4-(4-cyano-3-trifluoromethylphenylaminooxalyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1161783-84-1
2-[1-(tert-butoxycarbonyl)piperidin-4-yl]-2-oxoacetic acid

: 654-70-6
4-amino-2-trifluoromethylbenzonitrile

: 1161783-85-2
tert-butyl 4-(4-cyano-3-trifluoromethylphenylaminooxalyl)piperidine-1-carboxylate

Guidance literature:: 2-[1-(tert-butoxycarbonyl)piperidin-4-yl]-2-oxoacetic acid; With thionyl chloride; N,N-dimethyl acetamide; at 0 ℃;

4-amino-2-trifluoromethylbenzonitrile; at 20 ℃; for 18h;

Reference yield: 70.0%

: 1161783-85-2
tert-butyl 4-(4-cyano-3-trifluoromethylphenylaminooxalyl)piperidine-1-carboxylate

: 1589-82-8
phenylmagnesium bromide

: 1161063-50-8,1161065-19-5,1161066-91-6
tert-Butyl rac-4-[1-(4-cyano-3-trifluoromethylphenylcarbamoyl)-1-hydroxy-2-phenyl-ethyl]piperidine-1-carboxylate

Guidance literature:: tert-butyl 4-(4-cyano-3-trifluoromethylphenylaminooxalyl)piperidine-1-carboxylate; phenylmagnesium bromide; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; Inert atmosphere;

Reference yield:

: 352530-31-5
3-iodobenzylzinc bromide

: 1161783-85-2
tert-butyl 4-(4-cyano-3-trifluoromethylphenylaminooxalyl)piperidine-1-carboxylate

: 1161063-77-9,1161065-46-8,1161067-18-0
tert-butyl 4-[1-(4-cyano-3-trifluoromethylphenylcarbamoyl)-1-hydroxy-2-(3-iodophenyl)ethyl]piperidine-1-carboxylate

Guidance literature:: 3-iodobenzylzinc bromide; tert-butyl 4-(4-cyano-3-trifluoromethylphenylaminooxalyl)piperidine-1-carboxylate; In tetrahydrofuran; at -75 ℃; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; Inert atmosphere;