(S)-5-(bromomethyl)-5-(4-(trifluoromethyl)phenyl)dihydrofuran-2(3H)-one

Base Information

• Chemical Name: (S)-5-(bromomethyl)-5-(4-(trifluoromethyl)phenyl)dihydrofuran-2(3H)-one
• CAS No.: 1254701-65-9
• Molecular Formula: C₁₂H₁₀BrF₃O₂
• Molecular Weight: 323.109
• Mol file: 1254701-65-9.mol

Synonyms:(S)-5-(bromomethyl)-5-(4-(trifluoromethyl)phenyl)dihydrofuran-2(3H)-one

Chemical Property of (S)-5-(bromomethyl)-5-(4-(trifluoromethyl)phenyl)dihydrofuran-2(3H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-5-(bromomethyl)-5-(4-(trifluoromethyl)phenyl)dihydrofuran-2(3H)-one

There total 2 articles about (S)-5-(bromomethyl)-5-(4-(trifluoromethyl)phenyl)dihydrofuran-2(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4-(4-(trifluoromethyl)phenyl)-4-pentenoic acid (398142-10-4) → (S)-5-(bromomethyl)-5-(4-(trifluoromethyl)phenyl)dihydrofuran-2(3H)-one (1254701-65-9)

Guidance literature:

With N-Bromosuccinimide; N-((1S)-(2-(anthracen-9-yl)-6-methoxyquinolin-4-yl)((2R,5S)-5-vinylquinuclidin-2-yl)methyl)-2,4,6- trimethoxybenzamide; In o-xylene; toluene; at -60 ℃; for 48h; enantioselective reaction; Schlenk technique; Inert atmosphere; Darkness;

DOI:10.1021/jacs.1c05680

Reference yield:

4-(4-(trifluoromethyl)phenyl)-4-pentenoic acid (398142-10-4) → (S)-5-(bromomethyl)-5-(4-(trifluoromethyl)phenyl)dihydrofuran-2(3H)-one (1254701-65-9) + (R)-5-(bromomethyl)-5-(4-(trifluoromethyl)phenyl)dihydrofuran-2(3H)-one

Guidance literature:

With N-Bromosuccinimide; C₂₈H₃₁N₃O₃S; p-nitrobenzenesulfonamide; In chloroform; toluene; at -78 ℃; for 56h; optical yield given as %ee; enantioselective reaction; Inert atmosphere; Darkness;

DOI:10.1021/ja1048972

upstream raw materials:

4-(4-(trifluoromethyl)phenyl)-4-pentenoic acid