N-(6-(benzo[d][1,3]dioxol-5-ylmethyl)-3-cyano-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)-2,4-dichloro-5-(morpholinosulfonyl)benzamide

Base Information

Chemical Name:N-(6-(benzo[d][1,3]dioxol-5-ylmethyl)-3-cyano-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)-2,4-dichloro-5-(morpholinosulfonyl)benzamide
CAS No.:1449428-99-2
Molecular Formula:C₂₇H₂₄Cl₂N₄O₆S₂
Molecular Weight:635.549
Hs Code.:

Synonyms:N-(6-(benzo[d][1,3]dioxol-5-ylmethyl)-3-cyano-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)-2,4-dichloro-5-(morpholinosulfonyl)benzamide

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Chemical Property of N-(6-(benzo[d][1,3]dioxol-5-ylmethyl)-3-cyano-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)-2,4-dichloro-5-(morpholinosulfonyl)benzamide

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Technology Process of N-(6-(benzo[d][1,3]dioxol-5-ylmethyl)-3-cyano-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)-2,4-dichloro-5-(morpholinosulfonyl)benzamide

There total 9 articles about N-(6-(benzo[d][1,3]dioxol-5-ylmethyl)-3-cyano-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)-2,4-dichloro-5-(morpholinosulfonyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 120-57-0,30024-74-9
piperonal

: 1449428-77-6
ClH*C₁₉H₁₈Cl₂N₄O₄S₂

: 1449428-99-2
N-(6-(benzo[d][1,3]dioxol-5-ylmethyl)-3-cyano-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)-2,4-dichloro-5-(morpholinosulfonyl)benzamide

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In tetrahydrofuran; at 20 ℃;
DOI:10.1016/j.ejmech.2013.05.013

Reference yield:

: 2,4-dichloro-5-(morpholinosulfonyl)benzoyl chloride

: 1449428-99-2
N-(6-(benzo[d][1,3]dioxol-5-ylmethyl)-3-cyano-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)-2,4-dichloro-5-(morpholinosulfonyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / dichloromethane / 20 °C

2: dichloromethane / 2 h / 20 °C / Acidic conditions

3: acetic acid; sodium tris(acetoxy)borohydride / tetrahydrofuran / 20 °C

With pyridine; sodium tris(acetoxy)borohydride; acetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.ejmech.2013.05.013

Reference yield:

: 150986-83-7
2-amino-3-cyano-4,7-dihydro-5H-thieno[2,3-c]pyridine-6-carboxylic acid tert-butyl ester

: 1449428-99-2
N-(6-(benzo[d][1,3]dioxol-5-ylmethyl)-3-cyano-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)-2,4-dichloro-5-(morpholinosulfonyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / dichloromethane / 20 °C

2: dichloromethane / 2 h / 20 °C / Acidic conditions

3: acetic acid; sodium tris(acetoxy)borohydride / tetrahydrofuran / 20 °C

With pyridine; sodium tris(acetoxy)borohydride; acetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.ejmech.2013.05.013