Technology Process of (M*,3aR*,13aR*)-3a,4,13,13a-tetrahydro-6,11-dibenzoxy-7,10-dimethoxydibenzo-<4,5:6,7>cycloocta<1,2-c>furan-1(3H)-one
There total 9 articles about (M*,3aR*,13aR*)-3a,4,13,13a-tetrahydro-6,11-dibenzoxy-7,10-dimethoxydibenzo-<4,5:6,7>cycloocta<1,2-c>furan-1(3H)-one which
guide to synthetic route it.
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synthetic route:
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140161-10-0
(M*,3aR*,13aR*)-3a,4,13,13a-tetrahydro-6,11-dibenzoxy-7,10-dimethoxydibenzo-<4,5:6,7>cycloocta<1,2-c>furan-1(3H)-one
- Guidance literature:
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With
thallium (III) oxide; boron trifluoride diethyl etherate;
In
dichloromethane; trifluoroacetic acid;
for 0.25h;
Ambient temperature;
additional solvent: TFAA;
DOI:10.1016/S0040-4020(01)88186-2
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140161-10-0
(M*,3aR*,13aR*)-3a,4,13,13a-tetrahydro-6,11-dibenzoxy-7,10-dimethoxydibenzo-<4,5:6,7>cycloocta<1,2-c>furan-1(3H)-one
- Guidance literature:
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Multi-step reaction with 6 steps
1: 78 percent / NaOMe / methanol / 2 h / Heating
2: 1.) KOH; 2.) CaCl2, NaBH4 / 1.) EtOH, r.t.; 2.) aq. KOH, r.t., 3 h
3: 84 percent / H2 / 10percent Pd/C / acetic acid; ethyl acetate / 2585.7 Torr / Ambient temperature; overnight
4: 96 percent / K2CO3 / NaI / acetone / 10 h / Heating
5: 1.) n-BuLi, hexamethyldisilazane; 2.) hexamethylphosphoramide / 1.) THF, a) -78 deg C, 1 h, b) -30 deg C, 20 min; 2.) -78 deg C to r.t., 2 h
6: 69 percent / Tl2O3, BF3*Et2O / CH2Cl2; trifluoroacetic acid / 0.25 h / Ambient temperature; additional solvent: TFAA
With
N,N,N,N,N,N-hexamethylphosphoric triamide; potassium hydroxide; sodium tetrahydroborate; n-butyllithium; thallium (III) oxide; boron trifluoride diethyl etherate; hydrogen; sodium methylate; potassium carbonate; 1,1,1,3,3,3-hexamethyl-disilazane; calcium chloride;
palladium on activated charcoal; sodium iodide;
In
methanol; dichloromethane; acetic acid; ethyl acetate; acetone; trifluoroacetic acid;
DOI:10.1016/S0040-4020(01)88186-2
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140161-10-0
(M*,3aR*,13aR*)-3a,4,13,13a-tetrahydro-6,11-dibenzoxy-7,10-dimethoxydibenzo-<4,5:6,7>cycloocta<1,2-c>furan-1(3H)-one
- Guidance literature:
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Multi-step reaction with 3 steps
1: 96 percent / K2CO3 / NaI / acetone / 10 h / Heating
2: 1.) n-BuLi, hexamethyldisilazane; 2.) hexamethylphosphoramide / 1.) THF, a) -78 deg C, 1 h, b) -30 deg C, 20 min; 2.) -78 deg C to r.t., 2 h
3: 69 percent / Tl2O3, BF3*Et2O / CH2Cl2; trifluoroacetic acid / 0.25 h / Ambient temperature; additional solvent: TFAA
With
N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; thallium (III) oxide; boron trifluoride diethyl etherate; potassium carbonate; 1,1,1,3,3,3-hexamethyl-disilazane;
sodium iodide;
In
dichloromethane; acetone; trifluoroacetic acid;
DOI:10.1016/S0040-4020(01)88186-2
