4-(4-Fluoro-phenyl)-2,6-diisopropyl-3-((E)-2-methoxy-vinyl)-5-pentyl-pyridine

Base Information

Chemical Name:4-(4-Fluoro-phenyl)-2,6-diisopropyl-3-((E)-2-methoxy-vinyl)-5-pentyl-pyridine
CAS No.:202857-53-2
Molecular Formula:C₂₅H₃₄FNO
Molecular Weight:383.549
Hs Code.:

Synonyms:4-(4-Fluoro-phenyl)-2,6-diisopropyl-3-((E)-2-methoxy-vinyl)-5-pentyl-pyridine

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Chemical Property of 4-(4-Fluoro-phenyl)-2,6-diisopropyl-3-((E)-2-methoxy-vinyl)-5-pentyl-pyridine

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Technology Process of 4-(4-Fluoro-phenyl)-2,6-diisopropyl-3-((E)-2-methoxy-vinyl)-5-pentyl-pyridine

There total 9 articles about 4-(4-Fluoro-phenyl)-2,6-diisopropyl-3-((E)-2-methoxy-vinyl)-5-pentyl-pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 33670-32-5
methoxymethyltriphenylphosphonium bromide

: 202857-51-0
2,6-diisopropyl-4-(4-fluorophenyl)-5-pentyl-3-pyridinecarboxaldehyde

: 202857-53-2
4-(4-Fluoro-phenyl)-2,6-diisopropyl-3-((E)-2-methoxy-vinyl)-5-pentyl-pyridine

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran;
DOI:10.1016/S0960-894X(01)00766-1

Reference yield:

: 78168-82-8
ethyl 3-amino-4-methyl-pent-2-enoate

: 202857-53-2
4-(4-Fluoro-phenyl)-2,6-diisopropyl-3-((E)-2-methoxy-vinyl)-5-pentyl-pyridine

Guidance literature:: Multi-step reaction with 8 steps

1.2: DDQ / CH₂Cl₂

2.1: 67 percent / Red-Al / tetrahydrofuran

3.1: 99 percent / PCC / CH₂Cl₂

4.1: 90 percent / KOtBu / tetrahydrofuran

5.1: 80 percent / LiAlH₄ / tetrahydrofuran

6.1: 98 percent / H₂ / Pd/C / ethanol

7.1: 74 percent / PCC / CH₂Cl₂

8.1: 60 percent / KOtBu / tetrahydrofuran

With lithium aluminium tetrahydride; potassium tert-butylate; hydrogen; sodium bis(2-methoxyethoxy)aluminium dihydride; pyridinium chlorochromate; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; 4.1: Wittig reaction / 8.1: Wittig reaction;
DOI:10.1016/S0960-894X(01)00766-1

Reference yield:

: 7152-15-0
ethyl 4-methyl-3-oxo-pentanoate

: 202857-53-2
4-(4-Fluoro-phenyl)-2,6-diisopropyl-3-((E)-2-methoxy-vinyl)-5-pentyl-pyridine

Guidance literature:: Multi-step reaction with 9 steps

1.1: AcO-NH₄ / cyclohexane

2.2: DDQ / CH₂Cl₂

3.1: 67 percent / Red-Al / tetrahydrofuran

4.1: 99 percent / PCC / CH₂Cl₂

5.1: 90 percent / KOtBu / tetrahydrofuran

6.1: 80 percent / LiAlH₄ / tetrahydrofuran

7.1: 98 percent / H₂ / Pd/C / ethanol

8.1: 74 percent / PCC / CH₂Cl₂

9.1: 60 percent / KOtBu / tetrahydrofuran

With lithium aluminium tetrahydride; potassium tert-butylate; ammonium acetate; hydrogen; sodium bis(2-methoxyethoxy)aluminium dihydride; pyridinium chlorochromate; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; cyclohexane; 5.1: Wittig reaction / 9.1: Wittig reaction;
DOI:10.1016/S0960-894X(01)00766-1