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Technology Process of benzyl N-[3-methyl-1-oxo-1-[[(2S)-1-oxo-3-phenylpropan-2-yl]amino]butan-2-yl]carbamate

benzyl N-[3-methyl-1-oxo-1-[[(2S)-1-oxo-3-phenylpropan-2-yl]amino]butan-2-yl]carbamate

Base Information
  • Chemical Name:benzyl N-[3-methyl-1-oxo-1-[[(2S)-1-oxo-3-phenylpropan-2-yl]amino]butan-2-yl]carbamate
  • CAS No.:88191-84-8
  • Molecular Formula:C22H26N2O4
  • Molecular Weight:382.459
  • Hs Code.:2924297099
  • European Community (EC) Number:618-124-4
benzyl N-[3-methyl-1-oxo-1-[[(2S)-1-oxo-3-phenylpropan-2-yl]amino]butan-2-yl]carbamate

Synonyms:CalI III;calpain inhibitor III;carbobenzoxyvalylphenylalanine aldehyde;Cbz-Val-Phe-H;cBz-ValPheH;CbzValPheH;MDL 28170;MDL-28170;MDL28170;N-benzyloxycarbonylvalylphenylalaninal;N-benzyloxycarbonylvalylphenylalanine aldehyde;N-CBZ-Val-Phe-al

Suppliers and Price of benzyl N-[3-methyl-1-oxo-1-[[(2S)-1-oxo-3-phenylpropan-2-yl]amino]butan-2-yl]carbamate
Supply Marketing:
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • Usbiological
  • MDL 28170
  • 25mg
  • $ 403.00
  • Usbiological
  • MDL 28170
  • 10mg
  • $ 319.00
  • Sigma-Aldrich
  • MDL 28170 ≥95% (HPLC)
  • 25mg
  • $ 218.00
  • Medical Isotopes, Inc.
  • MDL 28170
  • 50 mg
  • $ 695.00
  • CSNpharm
  • MDL 28170
  • 50mg
  • $ 446.00
  • CSNpharm
  • MDL 28170
  • 25mg
  • $ 253.00
  • ChemScene
  • MDL 28170 >99.0%
  • 50mg
  • $ 225.00
  • ChemScene
  • MDL 28170 >99.0%
  • 25mg
  • $ 165.00
  • ChemScene
  • MDL 28170 >99.0%
  • 10mg
  • $ 115.00
  • ChemScene
  • MDL 28170 >99.0%
  • 5mg
  • $ 80.00
Total 27 raw suppliers
Chemical Property of benzyl N-[3-methyl-1-oxo-1-[[(2S)-1-oxo-3-phenylpropan-2-yl]amino]butan-2-yl]carbamate
Chemical Property:
  • Vapor Pressure:3.74E-14mmHg at 25°C 
  • Refractive Index:1.554 
  • Boiling Point:595.6 °C at 760 mmHg 
  • PKA:11.05±0.46(Predicted) 
  • Flash Point:314 °C 
  • PSA：84.50000 
  • Density:1.153 g/cm3 
  • LogP:3.64560 
  • Storage Temp.:2-8°C 
  • Solubility.:DMSO: 26 mg/mL 
  • XLogP3:2.7
  • Hydrogen Bond Donor Count:2
  • Hydrogen Bond Acceptor Count:4
  • Rotatable Bond Count:10
  • Exact Mass:382.18925731
  • Heavy Atom Count:28
  • Complexity:497
Purity/Quality:

99%, *data from raw suppliers

MDL 28170 *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
  • Safety Statements: 22-24/25 
MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:
  • Canonical SMILES:CC(C)C(C(=O)NC(CC1=CC=CC=C1)C=O)NC(=O)OCC2=CC=CC=C2
  • Isomeric SMILES:CC(C)C(C(=O)N[C@@H](CC1=CC=CC=C1)C=O)NC(=O)OCC2=CC=CC=C2
  • Description MDL-28170 (88191-84-8) is a potent and selective cell permeable calpain inhibitor. Inhibits oxidative damage-induced apoptosis in PC12 cells and capsaicin-induced apoptosis in dorsal root ganglion neurons.1?It penetrates the blood-brain barrier and inhibits brain cysteine protease activity after systemic administration, ameliorating brain damage in a gerbil model of global ischemia.2?Displays neuroprotective effects in neurotrauma rodent models.3?Calpain I Ki?= 8 nM; Cathepsin B Ki?= 24 nM in isolated enzyme assays. IC50?= 0.3 μM in intact cell assay.4
  • Uses MDL 28170 acts as a caplain inhibitor reducing hypoxia in ischemic-retinopathy, and various other neuroprotective effects. Inhibits calpain proteolysis
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