1,1-dimethylethyl <3R-<1(S),3R(S*)>>-methyl<1-<1-(1-phenylethyl)-3-pyrrolidinyl>ethyl>carbamate

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Chemical Name:1,1-dimethylethyl <3R-<1(S*),3R*(S*)>>-methyl<1-<1-(1-phenylethyl)-3-pyrrolidinyl>ethyl>carbamate
CAS No.:143444-97-7
Molecular Formula:C₂₀H₃₂N₂O₂
Molecular Weight:332.486
Hs Code.:

Synonyms:1,1-dimethylethyl <3R-<1(S*),3R*(S*)>>-methyl<1-<1-(1-phenylethyl)-3-pyrrolidinyl>ethyl>carbamate

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Chemical Property of 1,1-dimethylethyl <3R-<1(S*),3R*(S*)>>-methyl<1-<1-(1-phenylethyl)-3-pyrrolidinyl>ethyl>carbamate

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Technology Process of 1,1-dimethylethyl <3R-<1(S*),3R*(S*)>>-methyl<1-<1-(1-phenylethyl)-3-pyrrolidinyl>ethyl>carbamate

There total 4 articles about 1,1-dimethylethyl <3R-<1(S*),3R*(S*)>>-methyl<1-<1-(1-phenylethyl)-3-pyrrolidinyl>ethyl>carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 143444-94-4
<3R-<1(S*),3R*(S*)>>-N,α-dimethyl-1-(1-phenylethyl)-3-pyrrolidinemethanamine

: 143444-97-7
1,1-dimethylethyl <3R-<1(S*),3R*(S*)>>-methyl<1-<1-(1-phenylethyl)-3-pyrrolidinyl>ethyl>carbamate

Guidance literature:: With triethylamine; In dichloromethane; for 20h; Ambient temperature;
DOI:10.1002/jhet.5570290620

Reference yield:

: -4-<1-(hydroxyimino)ethyl>-1-(1-phenylethyl)-2-pyrrolidinone

: 143444-97-7
1,1-dimethylethyl <3R-<1(S*),3R*(S*)>>-methyl<1-<1-(1-phenylethyl)-3-pyrrolidinyl>ethyl>carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: 34 percent / NH₃, H₂ / Raney nickel / methanol / 23 h / 2585.7 - 2637.5 Torr

2: 88 percent / triethylamine / CH₂Cl₂ / 20 h / Ambient temperature

3: 94 percent / lithium aluminium hydride / tetrahydrofuran / 24 h / Heating

4: 79 percent / triethylamine / CH₂Cl₂ / 20 h / Ambient temperature

With lithium aluminium tetrahydride; ammonia; hydrogen; triethylamine; nickel; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1002/jhet.5570290620

Reference yield:

: 143444-74-0
<4R-<1(S*),4R*(S*)>>-4-(1-aminoethyl)-1-(1-phenylethyl)-2-pyrrolidinone

: 143444-97-7
1,1-dimethylethyl <3R-<1(S*),3R*(S*)>>-methyl<1-<1-(1-phenylethyl)-3-pyrrolidinyl>ethyl>carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / triethylamine / CH₂Cl₂ / 20 h / Ambient temperature

2: 94 percent / lithium aluminium hydride / tetrahydrofuran / 24 h / Heating

3: 79 percent / triethylamine / CH₂Cl₂ / 20 h / Ambient temperature

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1002/jhet.5570290620