tert-butyl {(3S)-1-[5-amino-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-yl]piperidin-3-yl}carbamate

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Chemical Name:tert-butyl {(3S)-1-[5-amino-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-yl]piperidin-3-yl}carbamate
CAS No.:1620012-25-0
Molecular Formula:C₂₄H₃₂N₆O₃
Molecular Weight:452.556
Hs Code.:

Synonyms:tert-butyl {(3S)-1-[5-amino-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-yl]piperidin-3-yl}carbamate

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Chemical Property of tert-butyl {(3S)-1-[5-amino-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-yl]piperidin-3-yl}carbamate

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Technology Process of tert-butyl {(3S)-1-[5-amino-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-yl]piperidin-3-yl}carbamate

There total 6 articles about tert-butyl {(3S)-1-[5-amino-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-yl]piperidin-3-yl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: C₁₉H₂₄N₆O

: 1620012-25-0
tert-butyl {(3S)-1-[5-amino-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-yl]piperidin-3-yl}carbamate

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 - 30 ℃; for 3h;

Reference yield:

: 1620012-22-7
ethyl 4-{(3S)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylate

: 1620012-25-0
tert-butyl {(3S)-1-[5-amino-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-yl]piperidin-3-yl}carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 50 °C

2: diphenyl phosphoryl azide; N-ethyl-N,N-diisopropylamine / tert-butyl alcohol / Reflux

3: hydrogenchloride / 1,4-dioxane / 2 h / 20 - 30 °C

4: triethylamine / tetrahydrofuran / 3 h / 20 - 30 °C

With hydrogenchloride; diphenyl phosphoryl azide; water; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; tert-butyl alcohol;

Reference yield:

: 227617-16-5
ethyl 4-chloro-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylate

: 1620012-25-0
tert-butyl {(3S)-1-[5-amino-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-yl]piperidin-3-yl}carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine / butan-1-ol / 14 h / 140 °C

2: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 50 °C

3: diphenyl phosphoryl azide; N-ethyl-N,N-diisopropylamine / tert-butyl alcohol / Reflux

4: hydrogenchloride / 1,4-dioxane / 2 h / 20 - 30 °C

5: triethylamine / tetrahydrofuran / 3 h / 20 - 30 °C

With hydrogenchloride; diphenyl phosphoryl azide; water; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; tert-butyl alcohol; butan-1-ol;