2-(N,N-diphenylcarbamoyl)oxy-9-(2-deoxy-β-D-erythro-pentofuranosyl)-9H-purine

Base Information

Chemical Name:2-(N,N-diphenylcarbamoyl)oxy-9-(2-deoxy-β-D-erythro-pentofuranosyl)-9H-purine
CAS No.:180477-13-8
Molecular Formula:C₂₃H₂₁N₅O₅
Molecular Weight:447.45
Hs Code.:

Synonyms:2-(N,N-diphenylcarbamoyl)oxy-9-(2-deoxy-β-D-erythro-pentofuranosyl)-9H-purine

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Chemical Property of 2-(N,N-diphenylcarbamoyl)oxy-9-(2-deoxy-β-D-erythro-pentofuranosyl)-9H-purine

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Technology Process of 2-(N,N-diphenylcarbamoyl)oxy-9-(2-deoxy-β-D-erythro-pentofuranosyl)-9H-purine

There total 4 articles about 2-(N,N-diphenylcarbamoyl)oxy-9-(2-deoxy-β-D-erythro-pentofuranosyl)-9H-purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 83-01-2
diphenylcarbamic chloride

: 67616-35-7
2'-deoxyisoinosine

: 180477-13-8
2-(N,N-diphenylcarbamoyl)oxy-9-(2-deoxy-β-D-erythro-pentofuranosyl)-9H-purine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In pyridine; at 20 ℃; for 3h;
DOI:10.1080/15257770008045448

Reference yield:

: 9-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-2-ol

: 180477-13-8
2-(N,N-diphenylcarbamoyl)oxy-9-(2-deoxy-β-D-erythro-pentofuranosyl)-9H-purine

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine

2: 1.) DEAD, PPh₃, 2.) aq. NH₄OH / 1.) dioxane, 4 deg C, 30 min, 2.) MeOH, 30 min

3: 1.) iPr₂NEt, 2.) NaOH / 1.) pyridine, 20 min, 2.) pyridine, EtOH, 10 min

With pyridine; ammonium hydroxide; sodium hydroxide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate;
DOI:10.1016/S0040-4020(98)00820-5

Reference yield:

: 217074-34-5
Acetic acid (2R,3S,5R)-2-acetoxymethyl-5-(2-hydroxy-purin-9-yl)-tetrahydro-furan-3-yl ester

: 180477-13-8
2-(N,N-diphenylcarbamoyl)oxy-9-(2-deoxy-β-D-erythro-pentofuranosyl)-9H-purine

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) DEAD, PPh₃, 2.) aq. NH₄OH / 1.) dioxane, 4 deg C, 30 min, 2.) MeOH, 30 min

2: 1.) iPr₂NEt, 2.) NaOH / 1.) pyridine, 20 min, 2.) pyridine, EtOH, 10 min

With ammonium hydroxide; sodium hydroxide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate;
DOI:10.1016/S0040-4020(98)00820-5