N¹-(7-methoxy-1,5-naphthyridin-4-yl)-N⁴-(4-phenylphthalazin-1-yl)benzene-1,4-diamine

Base Information

• Chemical Name: N¹-(7-methoxy-1,5-naphthyridin-4-yl)-N⁴-(4-phenylphthalazin-1-yl)benzene-1,4-diamine
• CAS No.: 1071528-82-9
• Molecular Formula: C₂₉H₂₂N₆O
• Molecular Weight: 470.533

Synonyms:N¹-(7-methoxy-1,5-naphthyridin-4-yl)-N⁴-(4-phenylphthalazin-1-yl)benzene-1,4-diamine

Chemical Property of N¹-(7-methoxy-1,5-naphthyridin-4-yl)-N⁴-(4-phenylphthalazin-1-yl)benzene-1,4-diamine

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Technology Process of N¹-(7-methoxy-1,5-naphthyridin-4-yl)-N⁴-(4-phenylphthalazin-1-yl)benzene-1,4-diamine

There total 6 articles about N¹-(7-methoxy-1,5-naphthyridin-4-yl)-N⁴-(4-phenylphthalazin-1-yl)benzene-1,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

8-chloro-3-methoxy-1,5-naphthyridine (952059-69-7) + N1‐(4‐phenylphthalazin‐1‐yl)-benzene‐1,4‐diamine (945600-03-3) → N1-(7-methoxy-1,5-naphthyridin-4-yl)-N4-(4-phenylphthalazin-1-yl)benzene-1,4-diamine (1071528-82-9)

Guidance literature:

In N,N-dimethyl-formamide; at 70 ℃; for 17h; Sealed tube;

Reference yield:

3-bromo-5-methoxypyridine (50720-12-2) → N1-(7-methoxy-1,5-naphthyridin-4-yl)-N4-(4-phenylphthalazin-1-yl)benzene-1,4-diamine (1071528-82-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: copper(II) sulfate; ammonium hydroxide / water / 4 h / 135 °C

2.1: 2 h / 100 - 105 °C

2.2: 4 h / Heating

3.1: diphenylether / 0.08 h / 240 - 250 °C / Inert atmosphere

4.1: trichlorophosphate / 12 h / 120 °C

5.1: N,N-dimethyl-formamide / 17 h / 70 °C / Sealed tube

With ammonium hydroxide; copper(II) sulfate; trichlorophosphate; In diphenylether; water; N,N-dimethyl-formamide;

Reference yield:

3,5-dibromopyridine (625-92-3) → N1-(7-methoxy-1,5-naphthyridin-4-yl)-N4-(4-phenylphthalazin-1-yl)benzene-1,4-diamine (1071528-82-9)

Guidance literature:

Multi-step reaction with 6 steps

1.1: sodium

1.2: 2 h / 90 °C

2.1: copper(II) sulfate; ammonium hydroxide / water / 4 h / 135 °C

3.1: 2 h / 100 - 105 °C

3.2: 4 h / Heating

4.1: diphenylether / 0.08 h / 240 - 250 °C / Inert atmosphere

5.1: trichlorophosphate / 12 h / 120 °C

6.1: N,N-dimethyl-formamide / 17 h / 70 °C / Sealed tube

With ammonium hydroxide; sodium; copper(II) sulfate; trichlorophosphate; In diphenylether; water; N,N-dimethyl-formamide;

upstream raw materials:

8-chloro-3-methoxy-1,5-naphthyridine

N¹‐(4‐phenylphthalazin‐1‐yl)-benzene‐1,4‐diamine

3-bromo-5-methoxypyridine

3,5-dibromopyridine

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